http://www.tkuhn.ch/bel2nanopub/RACxV1Xms-Ur_NjyA2mYF30zQwCnSEuV1w7EN1fp06Y4c#Head http://www.tkuhn.ch/bel2nanopub/RACxV1Xms-Ur_NjyA2mYF30zQwCnSEuV1w7EN1fp06Y4c http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RACxV1Xms-Ur_NjyA2mYF30zQwCnSEuV1w7EN1fp06Y4c#assertion http://www.tkuhn.ch/bel2nanopub/RACxV1Xms-Ur_NjyA2mYF30zQwCnSEuV1w7EN1fp06Y4c http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RACxV1Xms-Ur_NjyA2mYF30zQwCnSEuV1w7EN1fp06Y4c#provenance http://www.tkuhn.ch/bel2nanopub/RACxV1Xms-Ur_NjyA2mYF30zQwCnSEuV1w7EN1fp06Y4c http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RACxV1Xms-Ur_NjyA2mYF30zQwCnSEuV1w7EN1fp06Y4c#pubinfo http://www.tkuhn.ch/bel2nanopub/RACxV1Xms-Ur_NjyA2mYF30zQwCnSEuV1w7EN1fp06Y4c http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RACxV1Xms-Ur_NjyA2mYF30zQwCnSEuV1w7EN1fp06Y4c#assertion http://www.tkuhn.ch/bel2nanopub/RACxV1Xms-Ur_NjyA2mYF30zQwCnSEuV1w7EN1fp06Y4c#_1 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=30308 http://www.tkuhn.ch/bel2nanopub/RACxV1Xms-Ur_NjyA2mYF30zQwCnSEuV1w7EN1fp06Y4c#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697 http://www.tkuhn.ch/bel2nanopub/RACxV1Xms-Ur_NjyA2mYF30zQwCnSEuV1w7EN1fp06Y4c#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.obolibrary.org/obo/CLO_0007365 http://www.tkuhn.ch/bel2nanopub/RACxV1Xms-Ur_NjyA2mYF30zQwCnSEuV1w7EN1fp06Y4c#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RACxV1Xms-Ur_NjyA2mYF30zQwCnSEuV1w7EN1fp06Y4c#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RACxV1Xms-Ur_NjyA2mYF30zQwCnSEuV1w7EN1fp06Y4c#_1 http://www.tkuhn.ch/bel2nanopub/RACxV1Xms-Ur_NjyA2mYF30zQwCnSEuV1w7EN1fp06Y4c#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RACxV1Xms-Ur_NjyA2mYF30zQwCnSEuV1w7EN1fp06Y4c#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.ebi.ac.uk/chebi/searchId.do?chebiId=50113 http://www.tkuhn.ch/bel2nanopub/RACxV1Xms-Ur_NjyA2mYF30zQwCnSEuV1w7EN1fp06Y4c#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RACxV1Xms-Ur_NjyA2mYF30zQwCnSEuV1w7EN1fp06Y4c#assertion http://www.w3.org/2000/01/rdf-schema#label a(CHEBI:androgen) -> r(HGNC:RGMA) http://www.tkuhn.ch/bel2nanopub/RACxV1Xms-Ur_NjyA2mYF30zQwCnSEuV1w7EN1fp06Y4c#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RACxV1Xms-Ur_NjyA2mYF30zQwCnSEuV1w7EN1fp06Y4c#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RACxV1Xms-Ur_NjyA2mYF30zQwCnSEuV1w7EN1fp06Y4c#_3 http://www.w3.org/ns/prov#value The human prostate gland is an important target organ of androgenic hormones. Testosterone and dihydrotestosterone interact with the androgen receptor to regulate vital aspects of prostate growth and function including cellular proliferation, differentiation, apoptosis, metabolism, and secretory activity. Our objective in this study was to characterize the temporal program of transcription that reflects the cellular response to androgens and to identify specific androgen-regulated genes (ARGs) or gene networks that participate in these responses. We used cDNA microarrays representing about 20,000 distinct human genes to profile androgen-responsive transcripts in the LNCaP adenocarcinoma cell line and identified 146 genes with transcript alterations more than 3-fold. Of these, 103 encode proteins with described functional roles, and 43 represent transcripts that have yet to be characterized. Temporal gene expression profiles grouped the ARGs into four distinct cohorts. Five uncharacterized ARGs demonstrated exclusive or high expression levels in the prostate relative to other tissues studied. A search of available DNA sequence upstream of 28 ARGs identified 25 with homology to the androgen response-element consensus-binding motif. These results identify previously uncharacterized and unsuspected genes whose expression levels are directly or indirectly regulated by androgens; further, they provide a comprehensive temporal view of the transcriptional program of human androgen-responsive cells. http://www.tkuhn.ch/bel2nanopub/RACxV1Xms-Ur_NjyA2mYF30zQwCnSEuV1w7EN1fp06Y4c#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12185249 http://www.tkuhn.ch/bel2nanopub/RACxV1Xms-Ur_NjyA2mYF30zQwCnSEuV1w7EN1fp06Y4c#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RACxV1Xms-Ur_NjyA2mYF30zQwCnSEuV1w7EN1fp06Y4c#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12185249 http://www.tkuhn.ch/bel2nanopub/RACxV1Xms-Ur_NjyA2mYF30zQwCnSEuV1w7EN1fp06Y4c#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RACxV1Xms-Ur_NjyA2mYF30zQwCnSEuV1w7EN1fp06Y4c#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RACxV1Xms-Ur_NjyA2mYF30zQwCnSEuV1w7EN1fp06Y4c#_3 http://www.tkuhn.ch/bel2nanopub/RACxV1Xms-Ur_NjyA2mYF30zQwCnSEuV1w7EN1fp06Y4c#pubinfo http://www.tkuhn.ch/bel2nanopub/RACxV1Xms-Ur_NjyA2mYF30zQwCnSEuV1w7EN1fp06Y4c http://purl.org/dc/terms/created 2014-07-03T14:31:52.725+02:00 http://www.tkuhn.ch/bel2nanopub/RACxV1Xms-Ur_NjyA2mYF30zQwCnSEuV1w7EN1fp06Y4c http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RACxV1Xms-Ur_NjyA2mYF30zQwCnSEuV1w7EN1fp06Y4c http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234