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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RACvU8dMHS9mPi3oRxhPyE941t30nNEOtSVL-MLCcIvbY#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RACvU8dMHS9mPi3oRxhPyE941t30nNEOtSVL-MLCcIvbY#_4 http://www.w3.org/ns/prov#value {From full text} For example, phosphorylation of eIF2{alpha} by GCN2 (EIF2AK4) is enhanced by amino acid limitation, UV irradiation, and proteasome inhibition (13?16). Phosphorylation of eIF2{alpha} inhibits general protein synthesis by reducing the levels of eIF2-GTP that are required for binding of initiator tRNA to the translation apparatus. Concomitant with lowered protein synthesis, eIF2{alpha} phosphorylation leads to preferential translation of ATF4, a basic zipper (bZIP) transcription activator important for directing transcription of stress-related genes (17?20). Reduced protein synthesis conserves energy and provides the cell time for ATF4 and other stress-responsive transcription factors to reconfigure gene expression slated to alleviate damage elicited by the underlying stress. Other members of the eIF2 kinase family include PEK/Perk (EIF2AK3), whose activity is enhanced by endoplasmic reticulum (ER) stress (21, 22); HRI (EIF2AK1), which is regulated by heme deficiency and oxidative stress (23); and PKR (EIF2AK2), which functions in an antiviral pathway (24).{P@S52 is the common phosphorylation site between all 4 kinases and confirmed in Uniprot} http://www.tkuhn.ch/bel2nanopub/RACvU8dMHS9mPi3oRxhPyE941t30nNEOtSVL-MLCcIvbY#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/17170114 http://www.tkuhn.ch/bel2nanopub/RACvU8dMHS9mPi3oRxhPyE941t30nNEOtSVL-MLCcIvbY#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RACvU8dMHS9mPi3oRxhPyE941t30nNEOtSVL-MLCcIvbY#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/17170114 http://www.tkuhn.ch/bel2nanopub/RACvU8dMHS9mPi3oRxhPyE941t30nNEOtSVL-MLCcIvbY#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RACvU8dMHS9mPi3oRxhPyE941t30nNEOtSVL-MLCcIvbY#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RACvU8dMHS9mPi3oRxhPyE941t30nNEOtSVL-MLCcIvbY#_4 http://www.tkuhn.ch/bel2nanopub/RACvU8dMHS9mPi3oRxhPyE941t30nNEOtSVL-MLCcIvbY#pubinfo http://www.tkuhn.ch/bel2nanopub/RACvU8dMHS9mPi3oRxhPyE941t30nNEOtSVL-MLCcIvbY http://purl.org/dc/terms/created 2014-07-03T14:30:48.774+02:00 http://www.tkuhn.ch/bel2nanopub/RACvU8dMHS9mPi3oRxhPyE941t30nNEOtSVL-MLCcIvbY http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RACvU8dMHS9mPi3oRxhPyE941t30nNEOtSVL-MLCcIvbY http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234