@prefix this: <http://www.tkuhn.ch/bel2nanopub/RACvU8dMHS9mPi3oRxhPyE941t30nNEOtSVL-MLCcIvbY> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RACvU8dMHS9mPi3oRxhPyE941t30nNEOtSVL-MLCcIvbY#> .
@prefix beldoc: <http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix mgi: <http://www.informatics.jax.org/marker/MGI:> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 hasAgent: sub:_2;
    a go:0016301 .
  
  sub:_2 geneProductOf: mgi:1341830;
    a Protein: .
  
  sub:_3 occursIn: species:10090;
    rdf:object sub:_1;
    rdf:predicate belv:increases;
    rdf:subject go:0034976;
    a rdf:Statement .
  
  sub:assertion rdfs:label "bp(GO:\"response to endoplasmic reticulum stress\") -> kin(p(MGI:Eif2ak3))" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_5;
    pav:version "1.4" .
  
  sub:_4 prov:value "{From full text}  For example, phosphorylation of eIF2{alpha} by GCN2 (EIF2AK4) is enhanced by amino acid limitation, UV irradiation, and proteasome inhibition (13?16). Phosphorylation of eIF2{alpha} inhibits general protein synthesis by reducing the levels of eIF2-GTP that are required for binding of initiator tRNA to the translation apparatus. Concomitant with lowered protein synthesis, eIF2{alpha} phosphorylation leads to preferential translation of ATF4, a basic zipper (bZIP) transcription activator important for directing transcription of stress-related genes (17?20). Reduced protein synthesis conserves energy and provides the cell time for ATF4 and other stress-responsive transcription factors to reconfigure gene expression slated to alleviate damage elicited by the underlying stress. Other members of the eIF2 kinase family include PEK/Perk (EIF2AK3), whose activity is enhanced by endoplasmic reticulum (ER) stress (21, 22); HRI (EIF2AK1), which is regulated by heme deficiency and oxidative stress (23); and PKR (EIF2AK2), which functions in an antiviral pathway (24).{P@S52 is the common phosphorylation site between all 4 kinases and confirmed in Uniprot}";
    prov:wasQuotedFrom pubmed:17170114 .
  
  sub:_5 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:17170114;
    prov:wasDerivedFrom beldoc:, sub:_4 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:30:48.774+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}