. . . . . . . . . . . . . . . . . "a(CHEBI:nicotine) -> kin(p(RGD:Mapk3))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "20131211" . "The treatment of rat lung epithelial cells with nicotine for various periods differentially mobilizes multiple intracellular pathways [64]. Protein kinase C and PI3-OH-kinase are transiently activated after the treatment. Also, Ras and its downstream effector ERK1/2 are activated after long-term exposure to nicotine. The activation of Ras by nicotine treatment is responsible for the subsequent perturbation of the methotrexate (MTX)-mediated G1 cell cycle restriction, as well as an increase in production of reactive oxygen species [64]." . . "Selventa" . . . . "2014-07-03T14:33:21.446+02:00"^^ . . .