sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_5 ;
    pav:version "20131211" .
  sub:_4 prov:value "The treatment of rat lung epithelial cells with nicotine for various periods differentially mobilizes multiple intracellular pathways [64]. Protein kinase C and PI3-OH-kinase are transiently activated after the treatment. Also, Ras and its downstream effector ERK1/2 are activated after long-term exposure to nicotine. The activation of Ras by nicotine treatment is responsible for the subsequent perturbation of the methotrexate (MTX)-mediated G1 cell cycle restriction, as well as an increase in production of reactive oxygen species [64]." ;
    prov:wasQuotedFrom pubmed:18495523 .
  sub:_5 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:18495523 ;
    prov:wasDerivedFrom beldoc: , sub:_4 .
}