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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RACnI9zxHzuLEa6LHSBnorw9H2SLXZqyz28gtQKFCeB04#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RACnI9zxHzuLEa6LHSBnorw9H2SLXZqyz28gtQKFCeB04#_3 http://www.w3.org/ns/prov#value We hypothesized that ATMs recruited to adipose tissue during a high-fat diet have unique inflammatory properties compared with resident tissue ATMs. Using a dye (PKH26) to pulse label ATMs in vivo, we purified macrophages recruited to white adipose tissue during a high-fat diet. Comparison of gene expression in recruited and resident ATMs using real-time RT-PCR and cDNA microarrays showed that recruited ATMs overexpress genes important in macrophage migration and phagocytosis, including interleukin-6 (IL-6), inducible nitric oxide synthase (iNOS), and C-C chemokine receptor 2 (CCR2). #Table 2: genes overexpressed in recruited ATM compared to resident ATM# http://www.tkuhn.ch/bel2nanopub/RACnI9zxHzuLEa6LHSBnorw9H2SLXZqyz28gtQKFCeB04#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/17192460 http://www.tkuhn.ch/bel2nanopub/RACnI9zxHzuLEa6LHSBnorw9H2SLXZqyz28gtQKFCeB04#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RACnI9zxHzuLEa6LHSBnorw9H2SLXZqyz28gtQKFCeB04#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/17192460 http://www.tkuhn.ch/bel2nanopub/RACnI9zxHzuLEa6LHSBnorw9H2SLXZqyz28gtQKFCeB04#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RACnI9zxHzuLEa6LHSBnorw9H2SLXZqyz28gtQKFCeB04#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RACnI9zxHzuLEa6LHSBnorw9H2SLXZqyz28gtQKFCeB04#_3 http://www.tkuhn.ch/bel2nanopub/RACnI9zxHzuLEa6LHSBnorw9H2SLXZqyz28gtQKFCeB04#pubinfo http://www.tkuhn.ch/bel2nanopub/RACnI9zxHzuLEa6LHSBnorw9H2SLXZqyz28gtQKFCeB04 http://purl.org/dc/terms/created 2014-07-03T14:33:07.750+02:00 http://www.tkuhn.ch/bel2nanopub/RACnI9zxHzuLEa6LHSBnorw9H2SLXZqyz28gtQKFCeB04 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RACnI9zxHzuLEa6LHSBnorw9H2SLXZqyz28gtQKFCeB04 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234