http://www.tkuhn.ch/bel2nanopub/RACkCH9_C1C4wS1SNMKGTqgfN8OrEeq6JOaJ38br2Z27c#Head http://www.tkuhn.ch/bel2nanopub/RACkCH9_C1C4wS1SNMKGTqgfN8OrEeq6JOaJ38br2Z27c http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RACkCH9_C1C4wS1SNMKGTqgfN8OrEeq6JOaJ38br2Z27c#assertion http://www.tkuhn.ch/bel2nanopub/RACkCH9_C1C4wS1SNMKGTqgfN8OrEeq6JOaJ38br2Z27c http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RACkCH9_C1C4wS1SNMKGTqgfN8OrEeq6JOaJ38br2Z27c#provenance http://www.tkuhn.ch/bel2nanopub/RACkCH9_C1C4wS1SNMKGTqgfN8OrEeq6JOaJ38br2Z27c http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RACkCH9_C1C4wS1SNMKGTqgfN8OrEeq6JOaJ38br2Z27c#pubinfo http://www.tkuhn.ch/bel2nanopub/RACkCH9_C1C4wS1SNMKGTqgfN8OrEeq6JOaJ38br2Z27c http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RACkCH9_C1C4wS1SNMKGTqgfN8OrEeq6JOaJ38br2Z27c#assertion http://www.tkuhn.ch/bel2nanopub/RACkCH9_C1C4wS1SNMKGTqgfN8OrEeq6JOaJ38br2Z27c#_1 http://purl.obolibrary.org/obo/RO_0002204 http://www.informatics.jax.org/marker/MGI:1917592 http://www.tkuhn.ch/bel2nanopub/RACkCH9_C1C4wS1SNMKGTqgfN8OrEeq6JOaJ38br2Z27c#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RACkCH9_C1C4wS1SNMKGTqgfN8OrEeq6JOaJ38br2Z27c#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090 http://www.tkuhn.ch/bel2nanopub/RACkCH9_C1C4wS1SNMKGTqgfN8OrEeq6JOaJ38br2Z27c#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://purl.bioontology.org/ontology/MSH/D005334 http://www.tkuhn.ch/bel2nanopub/RACkCH9_C1C4wS1SNMKGTqgfN8OrEeq6JOaJ38br2Z27c#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RACkCH9_C1C4wS1SNMKGTqgfN8OrEeq6JOaJ38br2Z27c#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RACkCH9_C1C4wS1SNMKGTqgfN8OrEeq6JOaJ38br2Z27c#_1 http://www.tkuhn.ch/bel2nanopub/RACkCH9_C1C4wS1SNMKGTqgfN8OrEeq6JOaJ38br2Z27c#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RACkCH9_C1C4wS1SNMKGTqgfN8OrEeq6JOaJ38br2Z27c#assertion http://www.w3.org/2000/01/rdf-schema#label p(MGI:Ptges2) -> path(MESHD:Fever) http://www.tkuhn.ch/bel2nanopub/RACkCH9_C1C4wS1SNMKGTqgfN8OrEeq6JOaJ38br2Z27c#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RACkCH9_C1C4wS1SNMKGTqgfN8OrEeq6JOaJ38br2Z27c#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RACkCH9_C1C4wS1SNMKGTqgfN8OrEeq6JOaJ38br2Z27c#_3 http://www.w3.org/ns/prov#value It has been proposed that ciliary neurotrophic factor (CNTF) belongs to the group of cytokines causing fever in response to infectious and inflammatory noxae. The present investigation was undertaken in the conscious cat to verify whether CNTF (human type, hCNTF) is pyrogenic when given either intravenously (i.v.) or intracerebroventricularly (i.c.v.) and correlate at the same time body temperature with cerebrospinal fluid (CSF) levels of prostaglandin (PG) E2 (i.e., the putative fever mediator in brain) and thromboxane (TX) B2 (the stable TXA2 byproduct) in untreated vs. treated animals. hCNTF (10 microg/kg i.v.; 1 microg i.c.v.) caused fever by both routes and the increase in body temperature was associated with an upward change in CSF PGE2. Conversely, CSF TXB2 showed no elevation. Similarly unaffected was CSF TXB2 by human interleukin 6 (hIL-6, 1 microg i.c.v.), a cytokine with known pyrogenic and PGE2-promoting actions sharing the signal-transducing mechanism with hCNTF. We conclude that CNTF lends itself to a role in the pathogenesis of fever. The modest PGE2 elevation relatively to other cytokines, specifically hIL-1, is ascribed to the fact that CNTF activates the inducible isoform of arachidonate cyclooxygenase, which is constitutively expressed in brain, without concomitantly promoting the formation of new enzyme. http://www.tkuhn.ch/bel2nanopub/RACkCH9_C1C4wS1SNMKGTqgfN8OrEeq6JOaJ38br2Z27c#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/9434196 http://www.tkuhn.ch/bel2nanopub/RACkCH9_C1C4wS1SNMKGTqgfN8OrEeq6JOaJ38br2Z27c#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RACkCH9_C1C4wS1SNMKGTqgfN8OrEeq6JOaJ38br2Z27c#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/9434196 http://www.tkuhn.ch/bel2nanopub/RACkCH9_C1C4wS1SNMKGTqgfN8OrEeq6JOaJ38br2Z27c#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RACkCH9_C1C4wS1SNMKGTqgfN8OrEeq6JOaJ38br2Z27c#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RACkCH9_C1C4wS1SNMKGTqgfN8OrEeq6JOaJ38br2Z27c#_3 http://www.tkuhn.ch/bel2nanopub/RACkCH9_C1C4wS1SNMKGTqgfN8OrEeq6JOaJ38br2Z27c#pubinfo http://www.tkuhn.ch/bel2nanopub/RACkCH9_C1C4wS1SNMKGTqgfN8OrEeq6JOaJ38br2Z27c http://purl.org/dc/terms/created 2014-07-03T14:30:59.240+02:00 http://www.tkuhn.ch/bel2nanopub/RACkCH9_C1C4wS1SNMKGTqgfN8OrEeq6JOaJ38br2Z27c http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RACkCH9_C1C4wS1SNMKGTqgfN8OrEeq6JOaJ38br2Z27c http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234