@prefix this: . @prefix rdfs: . @prefix xsd: . @prefix sio: . @prefix ncit: . @prefix lld: . @prefix miriam-gene: . @prefix miriam-pubmed: . @prefix eco: . @prefix wi: . @prefix prov: . @prefix pav: . @prefix prv: . @prefix dcterms: . @prefix np: . @prefix dgn-np: . @prefix dgn-gda: . @prefix dgn-void: . dgn-np:NP699321.RACj-HTgX2AJq-JCfERMBERcdv0z3NT5mk3ePDFNLejXM130_head { this: np:hasAssertion dgn-np:NP699321.RACj-HTgX2AJq-JCfERMBERcdv0z3NT5mk3ePDFNLejXM130_assertion; np:hasProvenance dgn-np:NP699321.RACj-HTgX2AJq-JCfERMBERcdv0z3NT5mk3ePDFNLejXM130_provenance; np:hasPublicationInfo dgn-np:NP699321.RACj-HTgX2AJq-JCfERMBERcdv0z3NT5mk3ePDFNLejXM130_publicationInfo; a np:Nanopublication . dgn-np:NP699321.RACj-HTgX2AJq-JCfERMBERcdv0z3NT5mk3ePDFNLejXM130_assertion a np:Assertion . dgn-np:NP699321.RACj-HTgX2AJq-JCfERMBERcdv0z3NT5mk3ePDFNLejXM130_provenance a np:Provenance . dgn-np:NP699321.RACj-HTgX2AJq-JCfERMBERcdv0z3NT5mk3ePDFNLejXM130_publicationInfo a np:PublicationInfo . } dgn-np:NP699321.RACj-HTgX2AJq-JCfERMBERcdv0z3NT5mk3ePDFNLejXM130_assertion { miriam-gene:960 a ncit:C16612 . lld:C0003873 a ncit:C7057 . dgn-gda:DGN6173e7c67a9278d1469c062015cc2fb8 sio:SIO_000628 miriam-gene:960, lld:C0003873; a sio:SIO_001121 . } dgn-np:NP699321.RACj-HTgX2AJq-JCfERMBERcdv0z3NT5mk3ePDFNLejXM130_provenance { dgn-np:NP699321.RACj-HTgX2AJq-JCfERMBERcdv0z3NT5mk3ePDFNLejXM130_assertion dcterms:description "[In this study, we propose a novel function for CD44 using synovial cells from rheumatoid arthritis (RA) patients and demonstrated that CD44 cross-linking augmented Fas expression and subsequent Fas-mediated apoptosis of the cells: 1) cross-linking of CD44 on RA synovial cells markedly augmented Fas expression and its mRNA transcription; 2) engagement of CD44 up-regulated Fas on the cells within 3 h, much more than IL-1beta and TNF-alpha did; 3) the Fas-mediated early apoptotic change of the cells was amplified by CD44 cross-linking; and 4) hyaluronan, especially when fragmented, also augmented Fas-mediated early apoptosis of the cells.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en; wi:evidence dgn-void:source_evidence_literature; sio:SIO_000772 miriam-pubmed:11466334; prov:wasDerivedFrom dgn-void:befree-20140225; prov:wasGeneratedBy eco:ECO_0000203 . dgn-void:befree-20140225 pav:importedOn "2014-02-25"^^xsd:date . dgn-void:source_evidence_literature a eco:ECO_0000212; rdfs:comment "Gene-disease associations inferred from text-mining the literature."@en; rdfs:label "DisGeNET evidence - LITERATURE"@en . } dgn-np:NP699321.RACj-HTgX2AJq-JCfERMBERcdv0z3NT5mk3ePDFNLejXM130_publicationInfo { this: dcterms:created "2014-10-02T12:39:05+02:00"^^xsd:dateTime; dcterms:rights ; dcterms:rightsHolder dgn-void:IBIGroup; dcterms:subject sio:SIO_000983; prv:usedData dgn-void:disgenetrdf; pav:authoredBy , , , , ; pav:createdBy ; pav:version "v2.1.0.0" . dgn-void:disgenetrdf pav:version "v2.1.0" . }