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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RACfUWCvmof7gMi6-pI1nJ3i4lzOSjBsSNiMCafmI4rAM#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RACfUWCvmof7gMi6-pI1nJ3i4lzOSjBsSNiMCafmI4rAM#_4 http://purl.org/dc/elements/1.1/identifier Genstruct Top Level Model for Blood Coagulation http://www.tkuhn.ch/bel2nanopub/RACfUWCvmof7gMi6-pI1nJ3i4lzOSjBsSNiMCafmI4rAM#_4 http://purl.org/dc/elements/1.1/title Genstruct Top Level Model for Blood Coagulation http://www.tkuhn.ch/bel2nanopub/RACfUWCvmof7gMi6-pI1nJ3i4lzOSjBsSNiMCafmI4rAM#_4 http://purl.org/dc/elements/1.1/type Other http://www.tkuhn.ch/bel2nanopub/RACfUWCvmof7gMi6-pI1nJ3i4lzOSjBsSNiMCafmI4rAM#_5 http://www.w3.org/ns/prov#value kininogens; Endogenous peptides present in most body fluids. Certain enzymes convert them to active kinins which are involved in inflammation, blood clotting, complement reactions, etc. Kininogens belong to the cystatin superfamily. They are cysteine proteinase inhibitors. High-molecular-weight kininogen (hmwk) is split by plasma kallikrein to produce bradykinin. Low-molecular-weight kininogen (lmwk) is split by tissue kallikrein to produce kallidin. kinins; Inflammatory mediators that cause dilation of blood vessels and altered vascular permeability. Kinins are small peptides produced from kininogen by kallikrein and are broken down by kininases. Act on phospholipase and increase arachidonic acid release and thus prostaglandin (PGE2) production. bradykinin; Vasoactive nonapeptide (RPPGFSPFR) formed by action of proteases on kininogens. Very similar to kallidin (which has the same sequence but with an additional N terminal lysine). Bradykinin is a very potent vasodilator and increases permeability of post capillary venules, it acts on endothelial cells to activate phospholipase A2. It is also spasmogenic for some smooth muscle and will cause pain. kallidin; Decapeptide (lysyl bradykinin, amino acid sequence KRPPGFSPFR) produced in kidney. 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