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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RACdsCZjq-Hs33PeslydQZCEtD9OqANLl6wHbq1x58T40#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RACdsCZjq-Hs33PeslydQZCEtD9OqANLl6wHbq1x58T40#_3 http://www.w3.org/ns/prov#value To monitor the ability of ATRA and VD to activate the genetic program underlying monocytic differentiation in the M2 cellular context, we have investigated the expression of VD-responsive genes (Fig. 8) such as HMSE-1, CD14, and hOC by RT-PCR and the expression of genes controlled by a functional VDRE, such as p21waf-1 (51) , or RARE, such as E3 (52) , IRF-1 (53) and p21waf-1 (68) , by Northern blot analysis after different times of ATRA or VD treatment. Fig. 8 shows that both ATRA and VD treatment of Kasumi-1 cells causes a rapid induction of HMSE-1, CD14, and hOC expression, demonstrating VDR involvement in ATRA-dependent monocytic differentiation of M2-type blast cells. http://www.tkuhn.ch/bel2nanopub/RACdsCZjq-Hs33PeslydQZCEtD9OqANLl6wHbq1x58T40#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/10446999 http://www.tkuhn.ch/bel2nanopub/RACdsCZjq-Hs33PeslydQZCEtD9OqANLl6wHbq1x58T40#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RACdsCZjq-Hs33PeslydQZCEtD9OqANLl6wHbq1x58T40#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/10446999 http://www.tkuhn.ch/bel2nanopub/RACdsCZjq-Hs33PeslydQZCEtD9OqANLl6wHbq1x58T40#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RACdsCZjq-Hs33PeslydQZCEtD9OqANLl6wHbq1x58T40#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RACdsCZjq-Hs33PeslydQZCEtD9OqANLl6wHbq1x58T40#_3 http://www.tkuhn.ch/bel2nanopub/RACdsCZjq-Hs33PeslydQZCEtD9OqANLl6wHbq1x58T40#pubinfo http://www.tkuhn.ch/bel2nanopub/RACdsCZjq-Hs33PeslydQZCEtD9OqANLl6wHbq1x58T40 http://purl.org/dc/terms/created 2014-07-03T14:31:31.563+02:00 http://www.tkuhn.ch/bel2nanopub/RACdsCZjq-Hs33PeslydQZCEtD9OqANLl6wHbq1x58T40 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RACdsCZjq-Hs33PeslydQZCEtD9OqANLl6wHbq1x58T40 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234