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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RACZwFAWCQTVpMq2ZPrK4kdzyd-MzXZ_cQa62ZUJE7kYU#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RACZwFAWCQTVpMq2ZPrK4kdzyd-MzXZ_cQa62ZUJE7kYU#_4 http://www.w3.org/ns/prov#value We found that a fragment of the IL-6 promoter containing the site specifically binds highly purified NF-KB protein and the NF-KB protein in nuclear extracts of phorbol ester-induced Jurkat cells. Mutations of the NF-KB site abolished complex formation with both purified NF-KB and the nuclear extract protein. Transient expression of chloramphenicol acetyltransferase (CAT) plasmids containing the IL-6 promoter revealed very little activity of the promoter in U-937 monocytic cells and in HeLa cells before stimulation. 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