sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_5 ;
    pav:version "1.4" .
  sub:_4 prov:value "We found that a fragment of the IL-6 promoter containing the site specifically binds highly purified NF-KB protein and the NF-KB protein in nuclear extracts of phorbol ester-induced Jurkat cells. Mutations of the NF-KB site abolished complex formation with both purified NF-KB and the nuclear extract protein. Transient expression of chloramphenicol acetyltransferase (CAT) plasmids containing the IL-6 promoter revealed very little activity of the promoter in U-937 monocytic cells and in HeLa cells before stimulation. However, stimulation of U-937 and HeLa cells by inducers of NF-KB led to a dramatic increase in CAT activity." ;
    prov:wasQuotedFrom pubmed:2183031 .
  sub:_5 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:2183031 ;
    prov:wasDerivedFrom beldoc: , sub:_4 .
}