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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RACYFeYumler0JrcTlcWUzSjokuwBnaSREcgKdwMAuPd8#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RACYFeYumler0JrcTlcWUzSjokuwBnaSREcgKdwMAuPd8#_5 http://www.w3.org/ns/prov#value Lipoprotein lipase (LPL) plays a role in lipid usage in skeletal muscle by hydrolyzing plasma triglycerides into fatty acids, which are further utilized for beta-oxidation. Lipid usage is stimulated during fasting, diabetes mellitus and exercise, concomitant with enhanced LPL expression in skeletal muscle. Here we show that the forkhead type transcription factor FKHR is strongly induced in skeletal muscle in fasting mice, in mice with streptozotocin-induced diabetes and in mice after treadmill running. Ectopic expression of FKHR enhanced LPL gene expression in C2C12 muscle cells in culture. These results implicate FKHR as an important modulator of lipid metabolism in skeletal muscle. http://www.tkuhn.ch/bel2nanopub/RACYFeYumler0JrcTlcWUzSjokuwBnaSREcgKdwMAuPd8#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12586369 http://www.tkuhn.ch/bel2nanopub/RACYFeYumler0JrcTlcWUzSjokuwBnaSREcgKdwMAuPd8#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RACYFeYumler0JrcTlcWUzSjokuwBnaSREcgKdwMAuPd8#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12586369 http://www.tkuhn.ch/bel2nanopub/RACYFeYumler0JrcTlcWUzSjokuwBnaSREcgKdwMAuPd8#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RACYFeYumler0JrcTlcWUzSjokuwBnaSREcgKdwMAuPd8#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RACYFeYumler0JrcTlcWUzSjokuwBnaSREcgKdwMAuPd8#_5 http://www.tkuhn.ch/bel2nanopub/RACYFeYumler0JrcTlcWUzSjokuwBnaSREcgKdwMAuPd8#pubinfo http://www.tkuhn.ch/bel2nanopub/RACYFeYumler0JrcTlcWUzSjokuwBnaSREcgKdwMAuPd8 http://purl.org/dc/terms/created 2014-07-03T14:31:58.929+02:00 http://www.tkuhn.ch/bel2nanopub/RACYFeYumler0JrcTlcWUzSjokuwBnaSREcgKdwMAuPd8 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RACYFeYumler0JrcTlcWUzSjokuwBnaSREcgKdwMAuPd8 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234