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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RACYCEM5djeRFlNSVM2kZTxGRiZU-UHHrp4FCHmZEwFJ8#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RACYCEM5djeRFlNSVM2kZTxGRiZU-UHHrp4FCHmZEwFJ8#_5 http://www.w3.org/ns/prov#value To delineate possible signaling pathways accounting for these gene expression, a subset of specific kinase inhibitors, SB203580, PD98059, rapamycin, LY294002, and Ro-32-0432, which inhibit p38 (HOG), MEK (MAPKK), S6 kinase, PI3 kinase, and protein kinase C (PKC), respectively, were employed. The IEGs were classified into three categories according to their susceptibility to the inhibitors. Expression of the first group (c-fos, jun-B, egr-1, tis11, tis21, thrombospondin-1, erp, thyroid hormone receptor [N-10], cyr61, and zf9) was mainly dependent on PKC and MEK pathways, while that of the second class (gene33 and tis10) exhibited an additional dependence on PI3 kinase pathways. http://www.tkuhn.ch/bel2nanopub/RACYCEM5djeRFlNSVM2kZTxGRiZU-UHHrp4FCHmZEwFJ8#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/10600478 http://www.tkuhn.ch/bel2nanopub/RACYCEM5djeRFlNSVM2kZTxGRiZU-UHHrp4FCHmZEwFJ8#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RACYCEM5djeRFlNSVM2kZTxGRiZU-UHHrp4FCHmZEwFJ8#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/10600478 http://www.tkuhn.ch/bel2nanopub/RACYCEM5djeRFlNSVM2kZTxGRiZU-UHHrp4FCHmZEwFJ8#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RACYCEM5djeRFlNSVM2kZTxGRiZU-UHHrp4FCHmZEwFJ8#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RACYCEM5djeRFlNSVM2kZTxGRiZU-UHHrp4FCHmZEwFJ8#_5 http://www.tkuhn.ch/bel2nanopub/RACYCEM5djeRFlNSVM2kZTxGRiZU-UHHrp4FCHmZEwFJ8#pubinfo http://www.tkuhn.ch/bel2nanopub/RACYCEM5djeRFlNSVM2kZTxGRiZU-UHHrp4FCHmZEwFJ8 http://purl.org/dc/terms/created 2014-07-03T14:31:33.357+02:00 http://www.tkuhn.ch/bel2nanopub/RACYCEM5djeRFlNSVM2kZTxGRiZU-UHHrp4FCHmZEwFJ8 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RACYCEM5djeRFlNSVM2kZTxGRiZU-UHHrp4FCHmZEwFJ8 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234