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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RACXeLlw82nILSx92H521RjbNk6DuMICainn914pDGQ6U#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RACXeLlw82nILSx92H521RjbNk6DuMICainn914pDGQ6U#_4 http://www.w3.org/ns/prov#value The recruitment of tumor necrosis factor receptor-associated factors (TRAFs) 1, 2, 3, 5, and 6 to the CD40 cytoplasmic tail upon CD40 trimerization results in downstream signaling events that ultimately lead to CD40-dependent, thymus-dependent (TD) humoral immune responses. Previously, we have shown signaling through the C-terminal tail of CD40 in the absence of canonical TRAF-binding sites is capable of signaling through an alternative TRAF2-binding site. Here, we demonstrate that B cells from mice harboring CD40 with only the C-terminal tail can activate both canonical and noncanonical NFkappaB signaling pathways. Moreover, while lacking germinal center formation, several hallmarks of humoral immune responses including clonal B-cell activation/expansion, antibody isotype switching, and affinity maturation remain normal. This study demonstrates a new functional domain in CD40 that controls critical aspects of B-cell immunity in an in vivo setting. http://www.tkuhn.ch/bel2nanopub/RACXeLlw82nILSx92H521RjbNk6DuMICainn914pDGQ6U#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/17360936 http://www.tkuhn.ch/bel2nanopub/RACXeLlw82nILSx92H521RjbNk6DuMICainn914pDGQ6U#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RACXeLlw82nILSx92H521RjbNk6DuMICainn914pDGQ6U#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/17360936 http://www.tkuhn.ch/bel2nanopub/RACXeLlw82nILSx92H521RjbNk6DuMICainn914pDGQ6U#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RACXeLlw82nILSx92H521RjbNk6DuMICainn914pDGQ6U#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RACXeLlw82nILSx92H521RjbNk6DuMICainn914pDGQ6U#_4 http://www.tkuhn.ch/bel2nanopub/RACXeLlw82nILSx92H521RjbNk6DuMICainn914pDGQ6U#pubinfo http://www.tkuhn.ch/bel2nanopub/RACXeLlw82nILSx92H521RjbNk6DuMICainn914pDGQ6U http://purl.org/dc/terms/created 2014-07-03T14:33:09.533+02:00 http://www.tkuhn.ch/bel2nanopub/RACXeLlw82nILSx92H521RjbNk6DuMICainn914pDGQ6U http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RACXeLlw82nILSx92H521RjbNk6DuMICainn914pDGQ6U http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234