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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RACKZRi88R_3A3yYS5V7-_aLcpsUsJSZ-TIQCVuHN3Py0#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RACKZRi88R_3A3yYS5V7-_aLcpsUsJSZ-TIQCVuHN3Py0#_4 http://www.w3.org/ns/prov#value The p53 tumor suppressor is inhibited and destabilized by Mdm2. c-Abl is important for p53 activation under stress conditions. In response to DNA damage, c-Abl protects p53 by neutralizing the inhibitory effects of Mdm2. Hdm2 (human Mdm2) phosphorylation at Tyr394. Substitution of Tyr394 by Phe394 enhances the ability of Mdm2 to promote p53 degradation and to inhibit its transcriptional and apoptotic activities. Our results suggest that phosphorylation of Mdm2 by c-Abl impairs the inhibition of p53 by Mdm2, hence defining a novel mechanism by which c-Abl activates p53. Mutation studies revealed that N-terminal and C-terminal of mdm2 are both important for binding c-Abl. http://www.tkuhn.ch/bel2nanopub/RACKZRi88R_3A3yYS5V7-_aLcpsUsJSZ-TIQCVuHN3Py0#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12110584 http://www.tkuhn.ch/bel2nanopub/RACKZRi88R_3A3yYS5V7-_aLcpsUsJSZ-TIQCVuHN3Py0#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RACKZRi88R_3A3yYS5V7-_aLcpsUsJSZ-TIQCVuHN3Py0#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12110584 http://www.tkuhn.ch/bel2nanopub/RACKZRi88R_3A3yYS5V7-_aLcpsUsJSZ-TIQCVuHN3Py0#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RACKZRi88R_3A3yYS5V7-_aLcpsUsJSZ-TIQCVuHN3Py0#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RACKZRi88R_3A3yYS5V7-_aLcpsUsJSZ-TIQCVuHN3Py0#_4 http://www.tkuhn.ch/bel2nanopub/RACKZRi88R_3A3yYS5V7-_aLcpsUsJSZ-TIQCVuHN3Py0#pubinfo http://www.tkuhn.ch/bel2nanopub/RACKZRi88R_3A3yYS5V7-_aLcpsUsJSZ-TIQCVuHN3Py0 http://purl.org/dc/terms/created 2014-07-03T14:30:04.378+02:00 http://www.tkuhn.ch/bel2nanopub/RACKZRi88R_3A3yYS5V7-_aLcpsUsJSZ-TIQCVuHN3Py0 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RACKZRi88R_3A3yYS5V7-_aLcpsUsJSZ-TIQCVuHN3Py0 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234