sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_4 ;
    pav:version "20131211" .
  sub:_3 prov:value "Interestingly, the HO effector molecules biliverdin/bilirubin and CO have also been implicated in the modulation of a range of signaling pathways, including the cGMP and MAPK system, by which they may modulate inflammatory processes and also be involved in ROS-mediated signaling (Adeagbo, 1997; Siow et al., 1999; Otterbein et al., 2000; Nath et al., 2001b). It is likely that HO effector molecules bilirubin and CO, similar to anti-oxidants and NO (De Caterina et al., 1995), play a role in the regulation of ROS-mediated pathways, since HO-1 knockout mice show increased nuclear staining of NF-B after exposure to hemoglobin, compared with control mice (Nath et al., 2001b)." ;
    prov:wasQuotedFrom pubmed:12869663 .
  sub:_4 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:12869663 ;
    prov:wasDerivedFrom beldoc: , sub:_3 .
}