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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAC1NV18JqYBOlX9JVd08qM5C6_GOOKHRYJq7848-K2uY#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAC1NV18JqYBOlX9JVd08qM5C6_GOOKHRYJq7848-K2uY#_3 http://www.w3.org/ns/prov#value we pre-treated the monocytes with two different antioxidants, DPI (an inhibitor of flavoprotein-containing enzymes such as NADPH/NADPH oxidase) and Tiron (an O2 2 scavenger) to determine the role of reactive oxygen species (ROS). As shown in Figure 4A and B, DPI and Tiron abolished LTB4-induced MAPK pathways activation and NF-kB activation, respectively. These results show that LTB4 regulates MAPK and NF-kB pathways in a ROS-dependent mechanism. http://www.tkuhn.ch/bel2nanopub/RAC1NV18JqYBOlX9JVd08qM5C6_GOOKHRYJq7848-K2uY#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/18852255 http://www.tkuhn.ch/bel2nanopub/RAC1NV18JqYBOlX9JVd08qM5C6_GOOKHRYJq7848-K2uY#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAC1NV18JqYBOlX9JVd08qM5C6_GOOKHRYJq7848-K2uY#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/18852255 http://www.tkuhn.ch/bel2nanopub/RAC1NV18JqYBOlX9JVd08qM5C6_GOOKHRYJq7848-K2uY#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAC1NV18JqYBOlX9JVd08qM5C6_GOOKHRYJq7848-K2uY#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAC1NV18JqYBOlX9JVd08qM5C6_GOOKHRYJq7848-K2uY#_3 http://www.tkuhn.ch/bel2nanopub/RAC1NV18JqYBOlX9JVd08qM5C6_GOOKHRYJq7848-K2uY#pubinfo http://www.tkuhn.ch/bel2nanopub/RAC1NV18JqYBOlX9JVd08qM5C6_GOOKHRYJq7848-K2uY http://purl.org/dc/terms/created 2014-07-03T14:33:26.509+02:00 http://www.tkuhn.ch/bel2nanopub/RAC1NV18JqYBOlX9JVd08qM5C6_GOOKHRYJq7848-K2uY http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAC1NV18JqYBOlX9JVd08qM5C6_GOOKHRYJq7848-K2uY http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234