sub:assertion { d:DB05471v:identifier "DB05471" ; v:namespace "drugbank" ; v:uri "http://bio2rdf.org/drugbank:DB05471" ; v:x-identifiers.org <http://identifiers.org/drugbank/DB05471> ; dv:drugbank-id "DB05471" ; dv:x-cas <http://bio2rdf.org/cas:> ; dct:description """SGN-30 is an engineered monoclonal antibody (mAb) that reacts with significant affinity to the CD30 antigen, which is highly expressed on a variety of hematologic malignancies as compared to on normal cells. SGN-30 has been shown to induce direct anti-cancer activity towards tumor cells expressing CD30 and is undergoing phase II trials for cancer therapy. SGN-30 has demonstrated objective antitumor responses as a single agent in phase II clinical trials. We are collaborating with the National Cancer Institute (NCI) on three clinical trials of SGN-30 in combination with chemotherapy for the treatment of relapsed Hodgkin lymphoma, front-line ALCL and pediatric ALCL.