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Approximately 61,000 statements.
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Because Wnt5a binds to the receptor Frizzled-5, and by this interaction can exert its signaling effects (Ishikawa et al. 2001) and Sen et al. 2000 M. Sen, K. Lauterbach, H. El-Gabalawy, G.S. Firestein, M. Corr and D.A. Carson, Expression and function of wingless and frizzled homologs in rheumatoid arthritis, Proc. Natl. Acad. Sci. USA 97 (2000), pp. 2791?2796. View Record in Scopus | Cited By in Scopus (89)(Sen et al. 2000),.....Inhibition of the Fzd5 receptor results in a decrease in PKC activation. The Wnt5a transfectants were treated with a functional antibody to the receptor. This resulted in a decrease in PKC activation in the antibody-treated cells, but not the IgG-treated cells.
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