sub:provenance { beldoc:dce:description "Approximately 61,000 statements." ; dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ; dce:title "BEL Framework Large Corpus Document" ; pav:authoredBysub:_6 ; pav:version "20131211" . sub:_5prov:value "Reporter gene analyses identified sequences between -902 and -789, including consensus Ets and interferon regulatory factor elements, required for macrophage-specific and interferon gamma-inducible transcriptional activity. Pu.1 bound to the Ets site in electromobility shift assay and forced expression of Pu.1 activated the aif-1 promoter in 3T3 fibroblasts, in which it is normally inactive. Ets family transcription factor, Pu.1 (Sfpi1), and proteins interacting with a site meeting criteria for interferon regulatory factor (IRF) binding are required for expression of the aif-1 gene in both basal and interferon-gamma (IFN-gamma )-stimulated states." ; prov:wasQuotedFrompubmed:11861656 . sub:_6rdfs:label "Selventa" . sub:assertionprov:hadPrimarySourcepubmed:11861656 ; prov:wasDerivedFrombeldoc: , sub:_5 . }