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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RABo83WkYqvKrkQB9KpDDf6rKbqBeFYHVoIWbXkwY2LS0#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RABo83WkYqvKrkQB9KpDDf6rKbqBeFYHVoIWbXkwY2LS0#_3 http://www.w3.org/ns/prov#value In the present study, we examined the effects of rosiglitazone (RGZ) (rosaglitazone is a Pparg agonist) on insulin release and synthesis in pancreatic beta-cell (INS-1). Insulin release and synthesis were stimulated by treatment with RGZ for 24h. RGZ upregulated the expressions of GLUT-2 and glucokinase (GCK). Moreover, it was found that RGZ increased the expression of BETA2/NeuroD gene which could regulate insulin gene expression. http://www.tkuhn.ch/bel2nanopub/RABo83WkYqvKrkQB9KpDDf6rKbqBeFYHVoIWbXkwY2LS0#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/18191635 http://www.tkuhn.ch/bel2nanopub/RABo83WkYqvKrkQB9KpDDf6rKbqBeFYHVoIWbXkwY2LS0#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RABo83WkYqvKrkQB9KpDDf6rKbqBeFYHVoIWbXkwY2LS0#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/18191635 http://www.tkuhn.ch/bel2nanopub/RABo83WkYqvKrkQB9KpDDf6rKbqBeFYHVoIWbXkwY2LS0#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RABo83WkYqvKrkQB9KpDDf6rKbqBeFYHVoIWbXkwY2LS0#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RABo83WkYqvKrkQB9KpDDf6rKbqBeFYHVoIWbXkwY2LS0#_3 http://www.tkuhn.ch/bel2nanopub/RABo83WkYqvKrkQB9KpDDf6rKbqBeFYHVoIWbXkwY2LS0#pubinfo http://www.tkuhn.ch/bel2nanopub/RABo83WkYqvKrkQB9KpDDf6rKbqBeFYHVoIWbXkwY2LS0 http://purl.org/dc/terms/created 2014-07-03T14:30:52.469+02:00 http://www.tkuhn.ch/bel2nanopub/RABo83WkYqvKrkQB9KpDDf6rKbqBeFYHVoIWbXkwY2LS0 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RABo83WkYqvKrkQB9KpDDf6rKbqBeFYHVoIWbXkwY2LS0 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234