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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RABiQ6MeCY-IDBybgkI9-zSusKLvuJOa_5bZdo2MQvSEg#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RABiQ6MeCY-IDBybgkI9-zSusKLvuJOa_5bZdo2MQvSEg#_4 http://www.w3.org/ns/prov#value The gelsolin protein superfamily is a conserved family of proteins present in mammalian as well as in non-mammalian organisms. This review will focus on the role of gelsolin and gelsolin-related proteins in mammals. Gelsolin superfamily consists of seven different proteins: gelsolin, adseverin, villin, capG, advillin, supervillin and flightless I. All contain three or six homologous repeats of a domain named gelsolin-like (G) domain (fig. 1A). Gelsolin, a protein of 82-84 kDa, is the founding member of this family, exists as a cytoplasmic as well as a plasma isoform, and can bind, sever and cap actin filaments (reviewed in [2]). These isoforms are encoded by a single gene on chromosome 9 [3, 4]. The two messenger RNAs (mRNAs) encoding cytoplasmic and plasma isoforms result from alternative splicing and use alternative transcriptional initiation sites. Gelsolin is expressed in a wide variety of cell types. Its secreted form differs from the intracellular one by a 25-amino acid signaling peptide and the presence of a disulfide bond between cysteine residues at positions 188 and 201 [3, 5]. Recent studies show that the plasma gelsolin level decreases dramatically as a result of major trauma, and that reinfusion of gelsolin can protect against lung damage associated with major burn injury and other types of insults [6-8]. http://www.tkuhn.ch/bel2nanopub/RABiQ6MeCY-IDBybgkI9-zSusKLvuJOa_5bZdo2MQvSEg#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15526166 http://www.tkuhn.ch/bel2nanopub/RABiQ6MeCY-IDBybgkI9-zSusKLvuJOa_5bZdo2MQvSEg#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RABiQ6MeCY-IDBybgkI9-zSusKLvuJOa_5bZdo2MQvSEg#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15526166 http://www.tkuhn.ch/bel2nanopub/RABiQ6MeCY-IDBybgkI9-zSusKLvuJOa_5bZdo2MQvSEg#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RABiQ6MeCY-IDBybgkI9-zSusKLvuJOa_5bZdo2MQvSEg#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RABiQ6MeCY-IDBybgkI9-zSusKLvuJOa_5bZdo2MQvSEg#_4 http://www.tkuhn.ch/bel2nanopub/RABiQ6MeCY-IDBybgkI9-zSusKLvuJOa_5bZdo2MQvSEg#pubinfo http://www.tkuhn.ch/bel2nanopub/RABiQ6MeCY-IDBybgkI9-zSusKLvuJOa_5bZdo2MQvSEg http://purl.org/dc/terms/created 2014-07-03T14:30:29.415+02:00 http://www.tkuhn.ch/bel2nanopub/RABiQ6MeCY-IDBybgkI9-zSusKLvuJOa_5bZdo2MQvSEg http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RABiQ6MeCY-IDBybgkI9-zSusKLvuJOa_5bZdo2MQvSEg http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234