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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RABVypCdZ-ul-OI1ixmpGD4Mw7GynOaiqh4LuPctIusEI#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RABVypCdZ-ul-OI1ixmpGD4Mw7GynOaiqh4LuPctIusEI#_4 http://www.w3.org/ns/prov#value whereas formation of filopodia is mainly dependent on adseverin activity (adseverin is indeed expressed in these cells) [49]. Finally, knockout mice revealed the essential role of capG in macrophage ruffling [50]. Indeed, macrophages rapidly change shape forming protrusions resulting from local actin filament assembly [51], a process that is Ca2+ sensitive. In capG-/- mice, but not in Gsn-/- mice, basal and macrophage colony stimulating factor (MCSF)-induced ruffling activities were decreased [50]. A further role in phagocytosis Phagocytosis is a complex cellular process that necessitates a continuous rearrangement of actin cytoskeleton. In polymorphonuclear leukocytes three types of phagocytosis can be distinguished: a complement-opsonized, immunoglobulin G (IgG)-opsonized, and integrin-mediated phagocytosis. This latter is essential for remodeling of connective tissue. The three types of phagocytosis are mediated by three separate sets of cell surface receptors: the complement receptors (CRs), the Fc g receptors and integrin molecules [52-54]. Using Gsn-/- mice, it has been possible to demonstrate that gelsolin plays a primordial role in Fc receptor- and integrin- but not in complement- mediated phagocytosis [50, 54-56]. http://www.tkuhn.ch/bel2nanopub/RABVypCdZ-ul-OI1ixmpGD4Mw7GynOaiqh4LuPctIusEI#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15526166 http://www.tkuhn.ch/bel2nanopub/RABVypCdZ-ul-OI1ixmpGD4Mw7GynOaiqh4LuPctIusEI#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RABVypCdZ-ul-OI1ixmpGD4Mw7GynOaiqh4LuPctIusEI#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15526166 http://www.tkuhn.ch/bel2nanopub/RABVypCdZ-ul-OI1ixmpGD4Mw7GynOaiqh4LuPctIusEI#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RABVypCdZ-ul-OI1ixmpGD4Mw7GynOaiqh4LuPctIusEI#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RABVypCdZ-ul-OI1ixmpGD4Mw7GynOaiqh4LuPctIusEI#_4 http://www.tkuhn.ch/bel2nanopub/RABVypCdZ-ul-OI1ixmpGD4Mw7GynOaiqh4LuPctIusEI#pubinfo http://www.tkuhn.ch/bel2nanopub/RABVypCdZ-ul-OI1ixmpGD4Mw7GynOaiqh4LuPctIusEI http://purl.org/dc/terms/created 2014-07-03T14:32:34.495+02:00 http://www.tkuhn.ch/bel2nanopub/RABVypCdZ-ul-OI1ixmpGD4Mw7GynOaiqh4LuPctIusEI http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RABVypCdZ-ul-OI1ixmpGD4Mw7GynOaiqh4LuPctIusEI http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234