@prefix this: . @prefix sub: . @prefix beldoc: . @prefix rdfs: . @prefix rdf: . @prefix xsd: . @prefix dct: . @prefix dce: . @prefix pav: . @prefix np: . @prefix belv: . @prefix prov: . @prefix go: . @prefix Protein: . @prefix hgnc: . @prefix geneProductOf: . @prefix hasAgent: . @prefix species: . @prefix occursIn: . @prefix pubmed: . @prefix orcid: . sub:Head { this: np:hasAssertion sub:assertion; np:hasProvenance sub:provenance; np:hasPublicationInfo sub:pubinfo; a np:Nanopublication . } sub:assertion { sub:_1 hasAgent: sub:_2; a go:0003824 . sub:_2 geneProductOf: hgnc:4620; a Protein: . sub:_3 occursIn: species:9606; rdf:object go:0006909; rdf:predicate belv:increases; rdf:subject sub:_1; a rdf:Statement . sub:assertion rdfs:label "cat(p(HGNC:GSN)) -> bp(GOBP:phagocytosis)" . } sub:provenance { beldoc: dce:description "Approximately 61,000 statements."; dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved."; dce:title "BEL Framework Large Corpus Document"; pav:authoredBy sub:_5; pav:version "20131211" . sub:_4 prov:value "whereas formation of filopodia is mainly dependent on adseverin activity (adseverin is indeed expressed in these cells) [49]. Finally, knockout mice revealed the essential role of capG in macrophage ruffling [50]. Indeed, macrophages rapidly change shape forming protrusions resulting from local actin filament assembly [51], a process that is Ca2+ sensitive. In capG-/- mice, but not in Gsn-/- mice, basal and macrophage colony stimulating factor (MCSF)-induced ruffling activities were decreased [50]. A further role in phagocytosis Phagocytosis is a complex cellular process that necessitates a continuous rearrangement of actin cytoskeleton. In polymorphonuclear leukocytes three types of phagocytosis can be distinguished: a complement-opsonized, immunoglobulin G (IgG)-opsonized, and integrin-mediated phagocytosis. This latter is essential for remodeling of connective tissue. The three types of phagocytosis are mediated by three separate sets of cell surface receptors: the complement receptors (CRs), the Fc g receptors and integrin molecules [52-54]. Using Gsn-/- mice, it has been possible to demonstrate that gelsolin plays a primordial role in Fc receptor- and integrin- but not in complement- mediated phagocytosis [50, 54-56]."; prov:wasQuotedFrom pubmed:15526166 . sub:_5 rdfs:label "Selventa" . sub:assertion prov:hadPrimarySource pubmed:15526166; prov:wasDerivedFrom beldoc:, sub:_4 . } sub:pubinfo { this: dct:created "2014-07-03T14:32:34.495+02:00"^^xsd:dateTime; pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 . }