sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_5 ;
    pav:version "20131211" .
  sub:_4 prov:value "whereas formation of filopodia is mainly dependent on adseverin activity (adseverin is indeed expressed in these cells) [49]. Finally, knockout mice revealed the essential role of capG in macrophage ruffling [50]. Indeed, macrophages rapidly change shape forming protrusions resulting from local actin filament assembly [51], a process that is Ca2+ sensitive. In capG-/- mice, but not in Gsn-/- mice, basal and macrophage colony stimulating factor (MCSF)-induced ruffling activities were decreased [50]. A further role in phagocytosis Phagocytosis is a complex cellular process that necessitates a continuous rearrangement of actin cytoskeleton. In polymorphonuclear leukocytes three types of phagocytosis can be distinguished: a complement-opsonized, immunoglobulin G (IgG)-opsonized, and integrin-mediated phagocytosis. This latter is essential for remodeling of connective tissue. The three types of phagocytosis are mediated by three separate sets of cell surface receptors: the complement receptors (CRs), the Fc g receptors and integrin molecules [52-54]. Using Gsn-/- mice, it has been possible to demonstrate that gelsolin plays a primordial role in Fc receptor- and integrin- but not in complement- mediated phagocytosis [50, 54-56]." ;
    prov:wasQuotedFrom pubmed:15526166 .
  sub:_5 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:15526166 ;
    prov:wasDerivedFrom beldoc: , sub:_4 .
}