sub:provenance { beldoc:dce:description "Approximately 61,000 statements." ; dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ; dce:title "BEL Framework Large Corpus Document" ; pav:authoredBysub:_6 ; pav:version "1.4" . sub:_5prov:value "(From full text) In another approach to indirectly activate endogenous E2F, we employed mutant SAOS2 cells expressing temperature-sensitive pRB [47]. Shift of the culture to permissive temperature, allows the formation of pRB-E2F1 complexes, which would prevent the function of E2F resulting in the derepression of the PAI-1 gene. Accordingly, we found that shift of the culture to the permissive temperature induced PAI-1 mRNA (Fig. 3)Go. In contrast, the temperature shift had no effect on PAI-1 gene expression in control SAOS-2 cells." ; prov:wasQuotedFrompubmed:11559366 . sub:_6rdfs:label "Selventa" . sub:assertionprov:hadPrimarySourcepubmed:11559366 ; prov:wasDerivedFrombeldoc: , sub:_5 . }