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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RABOOmUkc4U2Q0GCjc0pHqkNchy-Zr5tipmMfCAor9Wbc#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RABOOmUkc4U2Q0GCjc0pHqkNchy-Zr5tipmMfCAor9Wbc#_5 http://www.w3.org/ns/prov#value We examined the effect of Dlx5 expression on the promoter activation of the steroidogenic acute regulatory protein (StAR) gene, which is essential for gonadal and adrenal steroidogenesis, in a Leydig cell line. Dlx5 efficiently activates the StAR promoter when GATA-4, another transcription factor essential for testicular steroidogenesis, was coexpressed. The transcriptional activation required the GATA-4-recognition element in the StAR promoter region and Dlx5 can physically interact with GATA-4. Furthermore, we herein show that the double inactivation of Dlx5 and Dlx6 in the mouse leads to decreased testosterone level and abnormal masculinization phenotype. http://www.tkuhn.ch/bel2nanopub/RABOOmUkc4U2Q0GCjc0pHqkNchy-Zr5tipmMfCAor9Wbc#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/18276760 http://www.tkuhn.ch/bel2nanopub/RABOOmUkc4U2Q0GCjc0pHqkNchy-Zr5tipmMfCAor9Wbc#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RABOOmUkc4U2Q0GCjc0pHqkNchy-Zr5tipmMfCAor9Wbc#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/18276760 http://www.tkuhn.ch/bel2nanopub/RABOOmUkc4U2Q0GCjc0pHqkNchy-Zr5tipmMfCAor9Wbc#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RABOOmUkc4U2Q0GCjc0pHqkNchy-Zr5tipmMfCAor9Wbc#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RABOOmUkc4U2Q0GCjc0pHqkNchy-Zr5tipmMfCAor9Wbc#_5 http://www.tkuhn.ch/bel2nanopub/RABOOmUkc4U2Q0GCjc0pHqkNchy-Zr5tipmMfCAor9Wbc#pubinfo http://www.tkuhn.ch/bel2nanopub/RABOOmUkc4U2Q0GCjc0pHqkNchy-Zr5tipmMfCAor9Wbc http://purl.org/dc/terms/created 2014-07-03T14:33:17.470+02:00 http://www.tkuhn.ch/bel2nanopub/RABOOmUkc4U2Q0GCjc0pHqkNchy-Zr5tipmMfCAor9Wbc http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RABOOmUkc4U2Q0GCjc0pHqkNchy-Zr5tipmMfCAor9Wbc http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234