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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RABO5WvLHBHXfD2K86GYSO1o0g1mgzx1sbpnOU7dFO0Ro#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RABO5WvLHBHXfD2K86GYSO1o0g1mgzx1sbpnOU7dFO0Ro#_3 http://www.w3.org/ns/prov#value Toward addressing this void, we used a mouse model in which calorie restriction produces alveolar loss, and ad libitum access to food after calorie restriction induces alveolar regeneration. We selected four processes (cell replication, angiogenesis, extracellular matrix remodeling, and guided cell motion) that would be required to convert a flat segment of alveolar wall into a septum that increases gas-exchange surface area. Global gene expression supportive of processes required to form a septum was present within 3 h of allowing calorie-restricted mice food ad libitum. One hour after providing calorie-restricted mice food ad libitum, RNA-level expression supportive of cell replication was present with little evidence of expression supportive of angiogenesis, extracellular matrix remodeling, or guided cell motion. Cell replication was more directly assayed by measuring DNA synthesis in lung. This measurement was made 3 h after allowing calorie-restricted mice food ad libitum because translation may be delayed. Ad libitum food intake, following calorie restriction, elevated DNA synthesis. (Table 2, 4, 6, 8, 10, 12, and 14) http://www.tkuhn.ch/bel2nanopub/RABO5WvLHBHXfD2K86GYSO1o0g1mgzx1sbpnOU7dFO0Ro#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/17237152 http://www.tkuhn.ch/bel2nanopub/RABO5WvLHBHXfD2K86GYSO1o0g1mgzx1sbpnOU7dFO0Ro#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RABO5WvLHBHXfD2K86GYSO1o0g1mgzx1sbpnOU7dFO0Ro#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/17237152 http://www.tkuhn.ch/bel2nanopub/RABO5WvLHBHXfD2K86GYSO1o0g1mgzx1sbpnOU7dFO0Ro#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RABO5WvLHBHXfD2K86GYSO1o0g1mgzx1sbpnOU7dFO0Ro#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RABO5WvLHBHXfD2K86GYSO1o0g1mgzx1sbpnOU7dFO0Ro#_3 http://www.tkuhn.ch/bel2nanopub/RABO5WvLHBHXfD2K86GYSO1o0g1mgzx1sbpnOU7dFO0Ro#pubinfo http://www.tkuhn.ch/bel2nanopub/RABO5WvLHBHXfD2K86GYSO1o0g1mgzx1sbpnOU7dFO0Ro http://purl.org/dc/terms/created 2014-07-03T14:30:49.073+02:00 http://www.tkuhn.ch/bel2nanopub/RABO5WvLHBHXfD2K86GYSO1o0g1mgzx1sbpnOU7dFO0Ro http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RABO5WvLHBHXfD2K86GYSO1o0g1mgzx1sbpnOU7dFO0Ro http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234