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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RABJxfvSUljX1H8y-HHreYq5NRYfrDiTqaskXpuGhxb6o#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RABJxfvSUljX1H8y-HHreYq5NRYfrDiTqaskXpuGhxb6o#_4 http://www.w3.org/ns/prov#value This observation, together with the very rapid kinetics of GSK3-beta phosphorylation in response to aortic coarctaction, supports the hypothesis that melusin selectively senses the biomechanical stimuli. In contrast to other kinases, GSK3-beta is highly active in unstimulated cells and becomes inactivated by phosphorylation of serine 9 in response to several stimuli28. Recent studies have shown that this inactivation is required for cardiac hypertrophy. In cardiomyocytes, active GSK3-beta phosphorylates the transcription factors NF-AT and GATA4, inducing their translocation from the nucleus to the cytoplasm and thus inhibiting their transcriptional activity25-27. 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