. . . . . . . . . . . . . . "kin(p(MGI:Gsk3b)) -| path(SDIS:\"cardiomyocyte hypertrophy\")" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "20131211" . "This observation, together with the very rapid kinetics of GSK3-beta phosphorylation in response to aortic coarctaction, supports the hypothesis that melusin selectively senses the biomechanical stimuli. In contrast to other kinases, GSK3-beta is highly active in unstimulated cells and becomes inactivated by phosphorylation of serine 9 in response to several stimuli28. Recent studies have shown that this inactivation is required for cardiac hypertrophy. In cardiomyocytes, active GSK3-beta phosphorylates the transcription factors NF-AT and GATA4, inducing their translocation from the nucleus to the cytoplasm and thus inhibiting their transcriptional activity25-27. In addition, active GSK3-beta also induces inhibition of elF2B, a principal initiation factor regulating protein synthesis." . . "Selventa" . . . . "2014-07-03T14:31:57.570+02:00"^^ . . .