sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_5 ;
    pav:version "20131211" .
  sub:_4 prov:value "This observation, together with the very rapid kinetics of GSK3-beta phosphorylation in response to aortic coarctaction, supports the hypothesis that melusin selectively senses the biomechanical stimuli. In contrast to other kinases, GSK3-beta is highly active in unstimulated cells and becomes inactivated by phosphorylation of serine 9 in response to several stimuli28. Recent studies have shown that this inactivation is required for cardiac hypertrophy. In cardiomyocytes, active GSK3-beta phosphorylates the transcription factors NF-AT and GATA4, inducing their translocation from the nucleus to the cytoplasm and thus inhibiting their transcriptional activity25-27. In addition, active GSK3-beta also induces inhibition of elF2B, a principal initiation factor regulating protein synthesis." ;
    prov:wasQuotedFrom pubmed:12496958 .
  sub:_5 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:12496958 ;
    prov:wasDerivedFrom beldoc: , sub:_4 .
}