sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_5 ;
    pav:version "1.4" .
  sub:_4 prov:value "Fibroblast like synoviocytes were incubated with TNF-alpha(10ng/ml). TNF-alpha induced an hsp70 response, resulting in transcriptional activation of HSF1 and enhanced hsp70 protein expression. TNF-alpha treated cells showed the formation of the hyperphosphorylated higher molecular weight isoform of HSF1. Activation of HSF1 by TNF-alpha was dose-dependent between 5 and 15 ng/ml of cytokine added to the  cultures. Time kinetics revealed maximum DNA binding activity of HSF1 after 3hours of cytokine incubation." ;
    prov:wasQuotedFrom pubmed:9664071 .
  sub:_5 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:9664071 ;
    prov:wasDerivedFrom beldoc: , sub:_4 .
}