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[Background-In long-QT syndrome (LQTS), heterozygosity for a mutation in 1 of the K(+) channel genes leads to prolongation of the cardiac action potential, because the aberrant protein exhibits loss of function. HERG, which is involved in LQT2, is the gene encoding the rapid component of the delayed rectifier, I(Kr).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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