[ {
  "@graph" : [ {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RABD1HPHqk56NNK4-R3UhvYDhd52Ycq3BNxrBzZmwhFsk",
    "@type" : [ "http://www.nanopub.org/nschema#Nanopublication" ],
    "http://www.nanopub.org/nschema#hasAssertion" : [ {
      "@id" : "http://www.tkuhn.ch/bel2nanopub/RABD1HPHqk56NNK4-R3UhvYDhd52Ycq3BNxrBzZmwhFsk#assertion"
    } ],
    "http://www.nanopub.org/nschema#hasProvenance" : [ {
      "@id" : "http://www.tkuhn.ch/bel2nanopub/RABD1HPHqk56NNK4-R3UhvYDhd52Ycq3BNxrBzZmwhFsk#provenance"
    } ],
    "http://www.nanopub.org/nschema#hasPublicationInfo" : [ {
      "@id" : "http://www.tkuhn.ch/bel2nanopub/RABD1HPHqk56NNK4-R3UhvYDhd52Ycq3BNxrBzZmwhFsk#pubinfo"
    } ]
  } ],
  "@id" : "http://www.tkuhn.ch/bel2nanopub/RABD1HPHqk56NNK4-R3UhvYDhd52Ycq3BNxrBzZmwhFsk#Head"
}, {
  "@graph" : [ {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RABD1HPHqk56NNK4-R3UhvYDhd52Ycq3BNxrBzZmwhFsk#_1",
    "@type" : [ "http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement" ],
    "http://purl.obolibrary.org/obo/BFO_0000066" : [ {
      "@id" : "http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606"
    } ],
    "http://www.w3.org/1999/02/22-rdf-syntax-ns#object" : [ {
      "@id" : "http://amigo.geneontology.org/amigo/term/GO:0048591"
    } ],
    "http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate" : [ {
      "@id" : "http://www.selventa.com/vocabulary/decreases"
    } ],
    "http://www.w3.org/1999/02/22-rdf-syntax-ns#subject" : [ {
      "@id" : "http://resource.belframework.org/belframework/20131211/namespace/selventa-legacy-chemicals/Trastuzumab"
    } ]
  }, {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RABD1HPHqk56NNK4-R3UhvYDhd52Ycq3BNxrBzZmwhFsk#assertion",
    "http://www.w3.org/2000/01/rdf-schema#label" : [ {
      "@value" : "a(SCHEM:Trastuzumab) -| bp(GOBP:\"cell growth\")"
    } ]
  } ],
  "@id" : "http://www.tkuhn.ch/bel2nanopub/RABD1HPHqk56NNK4-R3UhvYDhd52Ycq3BNxrBzZmwhFsk#assertion"
}, {
  "@graph" : [ {
    "@id" : "http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel",
    "http://purl.org/dc/elements/1.1/description" : [ {
      "@value" : "Approximately 61,000 statements."
    } ],
    "http://purl.org/dc/elements/1.1/rights" : [ {
      "@value" : "Copyright (c) 2011-2012, Selventa. All rights reserved."
    } ],
    "http://purl.org/dc/elements/1.1/title" : [ {
      "@value" : "BEL Framework Large Corpus Document"
    } ],
    "http://purl.org/pav/authoredBy" : [ {
      "@id" : "http://www.tkuhn.ch/bel2nanopub/RABD1HPHqk56NNK4-R3UhvYDhd52Ycq3BNxrBzZmwhFsk#_3"
    } ],
    "http://purl.org/pav/version" : [ {
      "@value" : "20131211"
    } ]
  }, {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RABD1HPHqk56NNK4-R3UhvYDhd52Ycq3BNxrBzZmwhFsk#_2",
    "http://www.w3.org/ns/prov#value" : [ {
      "@value" : "On the other hand, chemical FAS inhibitors as well as RNA interference-mediated silencing of FAS gene repress Her-2/neu gene expression at the transcriptional level. Moreover, specific FAS blockade synergistically sensitizes breast cancer cells carrying Her-2/neu-oncogene amplification and/or overexpression to trastuzumab-induced cell growth inhibition and apoptotic cell death. Strikingly, FAS inhibition synergistically interacts with trastuzumab in Her-2/neu-negative breast cancer cells engineered to overexpress Her-2/neu, thus suggesting that the molecular linkage between FAS activity and functioning of Her-2/neu cannot be explained only on the basis of a transcriptional repression of Her-2/neu gene promoter."
    } ],
    "http://www.w3.org/ns/prov#wasQuotedFrom" : [ {
      "@id" : "http://www.ncbi.nlm.nih.gov/pubmed/15780499"
    } ]
  }, {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RABD1HPHqk56NNK4-R3UhvYDhd52Ycq3BNxrBzZmwhFsk#_3",
    "http://www.w3.org/2000/01/rdf-schema#label" : [ {
      "@value" : "Selventa"
    } ]
  }, {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RABD1HPHqk56NNK4-R3UhvYDhd52Ycq3BNxrBzZmwhFsk#assertion",
    "http://www.w3.org/ns/prov#hadPrimarySource" : [ {
      "@id" : "http://www.ncbi.nlm.nih.gov/pubmed/15780499"
    } ],
    "http://www.w3.org/ns/prov#wasDerivedFrom" : [ {
      "@id" : "http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel"
    }, {
      "@id" : "http://www.tkuhn.ch/bel2nanopub/RABD1HPHqk56NNK4-R3UhvYDhd52Ycq3BNxrBzZmwhFsk#_2"
    } ]
  } ],
  "@id" : "http://www.tkuhn.ch/bel2nanopub/RABD1HPHqk56NNK4-R3UhvYDhd52Ycq3BNxrBzZmwhFsk#provenance"
}, {
  "@graph" : [ {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RABD1HPHqk56NNK4-R3UhvYDhd52Ycq3BNxrBzZmwhFsk",
    "http://purl.org/dc/terms/created" : [ {
      "@type" : "http://www.w3.org/2001/XMLSchema#dateTime",
      "@value" : "2014-07-03T14:32:41.930+02:00"
    } ],
    "http://purl.org/pav/createdBy" : [ {
      "@id" : "http://orcid.org/0000-0001-6818-334X"
    }, {
      "@id" : "http://orcid.org/0000-0002-1267-0234"
    } ]
  } ],
  "@id" : "http://www.tkuhn.ch/bel2nanopub/RABD1HPHqk56NNK4-R3UhvYDhd52Ycq3BNxrBzZmwhFsk#pubinfo"
} ]