. . . . . . . . . . . . . . "cat(p(HGNC:F2)) -> a(CHEBI:\"1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate\")" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "20131211" . " PtdIns(3,4)P2 and PtdIns(3,4,5)P3 are membrane-embedded and transduce signals, at least in part, by binding proteins via their specific PH or SH2 domains and recruiting them to the membrane. Examples include the PH domain-containing proteins, Akt, a serine-threonine kinase, and TIAM-1, a Rho family guanine nucleotide exchange protein; or the SH2 domain-containing proteins, phospholipase C and Src.85 In platelets, thrombin stimulates a rapid and transient increase in PtdIns(3,4,5)P3 and a later increase in PtdIns(3,4)P2." . . "Selventa" . . . . "2014-07-03T14:34:06.177+02:00"^^ . . .