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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAB49lpslcZPBuqVbR-TkAD9k-gc6JUiMAAe1dgTsc_RM#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAB49lpslcZPBuqVbR-TkAD9k-gc6JUiMAAe1dgTsc_RM#_3 http://www.w3.org/ns/prov#value The knockdown of EZH2 in cultured CC cells decreased p16 INK4a methylation and decreased binding of EZH2 to the p16 INK4a gene promoter. The latter suggested that direct binding of EZH2 is involved in the regulation of the p16 INK4a gene. Our data suggest that over-expression of EZH2 may induce hypermethylation of p16 INK4a promoter followed by decreased expression of p16 INK4a in the multi-step cholangiocarcinogenesis through intraepithelial neoplasm in hepatolithiasis. http://www.tkuhn.ch/bel2nanopub/RAB49lpslcZPBuqVbR-TkAD9k-gc6JUiMAAe1dgTsc_RM#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/18393368 http://www.tkuhn.ch/bel2nanopub/RAB49lpslcZPBuqVbR-TkAD9k-gc6JUiMAAe1dgTsc_RM#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAB49lpslcZPBuqVbR-TkAD9k-gc6JUiMAAe1dgTsc_RM#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/18393368 http://www.tkuhn.ch/bel2nanopub/RAB49lpslcZPBuqVbR-TkAD9k-gc6JUiMAAe1dgTsc_RM#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAB49lpslcZPBuqVbR-TkAD9k-gc6JUiMAAe1dgTsc_RM#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAB49lpslcZPBuqVbR-TkAD9k-gc6JUiMAAe1dgTsc_RM#_3 http://www.tkuhn.ch/bel2nanopub/RAB49lpslcZPBuqVbR-TkAD9k-gc6JUiMAAe1dgTsc_RM#pubinfo http://www.tkuhn.ch/bel2nanopub/RAB49lpslcZPBuqVbR-TkAD9k-gc6JUiMAAe1dgTsc_RM http://purl.org/dc/terms/created 2014-07-03T14:30:53.086+02:00 http://www.tkuhn.ch/bel2nanopub/RAB49lpslcZPBuqVbR-TkAD9k-gc6JUiMAAe1dgTsc_RM http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAB49lpslcZPBuqVbR-TkAD9k-gc6JUiMAAe1dgTsc_RM http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234