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Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAB3No9yHbx1L_gEUAPCJ4brXXarviQ6QnxXvmdXeLubA#_7 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAB3No9yHbx1L_gEUAPCJ4brXXarviQ6QnxXvmdXeLubA#_6 http://www.w3.org/ns/prov#value Tyrosine phosphorylation of IRS-1, as well as its association with p85{alpha} and activation of IRS-1-associated PI 3-kinase activity, decreased after 15-30 min of insulin stimulation in PTP1B+/+ neonatal hepatocytes (Fig. 4, upper panel). In sharp contrast, the effect of insulin on IRS-1 tyrosine phosphorylation in PTP1B-/- neonatal hepatocytes was prolonged; tyrosine phosphorylation of IRS-1, IRS-1/p85{alpha} association, and IRS-1-associated PI 3-kinase activity was sustained for 4 h in PTP1B-/- neonatal hepatocytes (Fig. 4, lower panel). Similar to findings for IRS-1, IRS-2 tyrosine phosphorylation, its binding to p85{alpha}, and activation of IRS-2-associated PI 3-kinase activity decreased between 15 and 60 min in insulin-stimulated PTP1B+/+ neonatal hepatocytes (Fig. 5, upper panel). However, insulin action was prolonged up to 4 h on this signaling pathway in PTP1B-/- neonatal hepatocytes (Fig. 5, lower panel). http://www.tkuhn.ch/bel2nanopub/RAB3No9yHbx1L_gEUAPCJ4brXXarviQ6QnxXvmdXeLubA#_6 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/17068137 http://www.tkuhn.ch/bel2nanopub/RAB3No9yHbx1L_gEUAPCJ4brXXarviQ6QnxXvmdXeLubA#_7 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAB3No9yHbx1L_gEUAPCJ4brXXarviQ6QnxXvmdXeLubA#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/17068137 http://www.tkuhn.ch/bel2nanopub/RAB3No9yHbx1L_gEUAPCJ4brXXarviQ6QnxXvmdXeLubA#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAB3No9yHbx1L_gEUAPCJ4brXXarviQ6QnxXvmdXeLubA#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAB3No9yHbx1L_gEUAPCJ4brXXarviQ6QnxXvmdXeLubA#_6 http://www.tkuhn.ch/bel2nanopub/RAB3No9yHbx1L_gEUAPCJ4brXXarviQ6QnxXvmdXeLubA#pubinfo http://www.tkuhn.ch/bel2nanopub/RAB3No9yHbx1L_gEUAPCJ4brXXarviQ6QnxXvmdXeLubA http://purl.org/dc/terms/created 2014-07-03T14:33:05.214+02:00 http://www.tkuhn.ch/bel2nanopub/RAB3No9yHbx1L_gEUAPCJ4brXXarviQ6QnxXvmdXeLubA http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAB3No9yHbx1L_gEUAPCJ4brXXarviQ6QnxXvmdXeLubA http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234