. . . . . . . . . . . . . . . . . . . . . "a(SCHEM:\"serum insulin\") -> p(MGI:Irs2,pmod(P,Y))" . "phos(p(MGI:Ptpn1)) -| (a(SCHEM:\"serum insulin\") -> p(MGI:Irs2,pmod(P,Y)))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "20131211" . "Tyrosine phosphorylation of IRS-1, as well as its association with p85{alpha} and activation of IRS-1-associated PI 3-kinase activity, decreased after 15-30 min of insulin stimulation in PTP1B+/+ neonatal hepatocytes (Fig. 4, upper panel). In sharp contrast, the effect of insulin on IRS-1 tyrosine phosphorylation in PTP1B-/- neonatal hepatocytes was prolonged; tyrosine phosphorylation of IRS-1, IRS-1/p85{alpha} association, and IRS-1-associated PI 3-kinase activity was sustained for 4 h in PTP1B-/- neonatal hepatocytes (Fig. 4, lower panel). Similar to findings for IRS-1, IRS-2 tyrosine phosphorylation, its binding to p85{alpha}, and activation of IRS-2-associated PI 3-kinase activity decreased between 15 and 60 min in insulin-stimulated PTP1B+/+ neonatal hepatocytes (Fig. 5, upper panel). However, insulin action was prolonged up to 4 h on this signaling pathway in PTP1B-/- neonatal hepatocytes (Fig. 5, lower panel). " . . "Selventa" . . . . "2014-07-03T14:33:05.214+02:00"^^ . . .