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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAAx9DQMUosSJrbWuz-pqPSDXHV4-0nX7Kk-7etrHlelo#_7 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAAx9DQMUosSJrbWuz-pqPSDXHV4-0nX7Kk-7etrHlelo#_6 http://www.w3.org/ns/prov#value From full text: TLRs signal through two main pathways, defined by the adaptor molecules used at the start of each. The best characterized of these is the MyD88-dependent pathway, common to all TLRs except TLR3, which results in rapid activation of the transcription molecules nuclear factor ?B (NF-?B), activator protein 1 and Elk-1 and induction of proinflammatory mediators such as tumour necrosis factor-? (TNF-?), interleukin-6 (IL-6) and cyclooxygenase-2.13,14 Activation of the NF-?B p65 and activator protein 1 transcription factors is reduced in endotoxin-tolerant cells.15 TLR7, -8 and -9 can also induce type I interferon (IFN) production in a MyD88-dependent manner, involving the activation of the interferon regulatory factor 5 (IRF-5)16 and IRF-717 transcription factors. The second, less well-studied pathway is thought to be limited to TLR3 and TLR4. TLR signalling via the adaptor molecules Toll/IL-1-receptor-domain-containing adaptor inducing IFN-? (TRIF) and TRIF-related adaptor molecule (TRAM) activates IRF-3 and IRF-7 and, ultimately, IFN-inducible genes such as IFN-?-inducible protein 10 (IP-10) and RANTES, via type I IFN production and autocrine activation of the JAK/STAT pathway http://www.tkuhn.ch/bel2nanopub/RAAx9DQMUosSJrbWuz-pqPSDXHV4-0nX7Kk-7etrHlelo#_6 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/17034424 http://www.tkuhn.ch/bel2nanopub/RAAx9DQMUosSJrbWuz-pqPSDXHV4-0nX7Kk-7etrHlelo#_7 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAAx9DQMUosSJrbWuz-pqPSDXHV4-0nX7Kk-7etrHlelo#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/17034424 http://www.tkuhn.ch/bel2nanopub/RAAx9DQMUosSJrbWuz-pqPSDXHV4-0nX7Kk-7etrHlelo#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAAx9DQMUosSJrbWuz-pqPSDXHV4-0nX7Kk-7etrHlelo#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAAx9DQMUosSJrbWuz-pqPSDXHV4-0nX7Kk-7etrHlelo#_6 http://www.tkuhn.ch/bel2nanopub/RAAx9DQMUosSJrbWuz-pqPSDXHV4-0nX7Kk-7etrHlelo#pubinfo http://www.tkuhn.ch/bel2nanopub/RAAx9DQMUosSJrbWuz-pqPSDXHV4-0nX7Kk-7etrHlelo http://purl.org/dc/terms/created 2014-07-03T14:30:46.640+02:00 http://www.tkuhn.ch/bel2nanopub/RAAx9DQMUosSJrbWuz-pqPSDXHV4-0nX7Kk-7etrHlelo http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAAx9DQMUosSJrbWuz-pqPSDXHV4-0nX7Kk-7etrHlelo http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234