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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAAsYyvqim4nIjbm1cn0OelrzLq_aWE1uG8rdFGlx4gYc#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAAsYyvqim4nIjbm1cn0OelrzLq_aWE1uG8rdFGlx4gYc#_4 http://www.w3.org/ns/prov#value Regulation of cell migration appears to implicate a cross talk with Rhofamily proteins. In migrating cells, PKB/Akt localizes to the leading edge [79], a site of high Rac activity [80]. In endothelial cells PKB/Akt has been reported to be both upstream and downstream of Rac and Cdc42 [81-83]. Endothelial cell migration induced by VEGFR2- stimulation involves integrin activation via a PI-3K and PKB/Akt-dependent signaling pathway [84]. Rho family GTPases. The small GTPases Rho, Rac and Cdc42 participate in the regulation of actin polymerization necessary for the formation of stress fibers, focal adhesions, lamellipodia and filopodia [85], and modulate cell proliferation and gene expression [86,87]. Integrin ligation activates Rho proteins by promoting GTP loading and translocation from the cytosol to the membrane [88]. Rac activity is essential for endothelial cell migration and angiogenesis [89,90] and this effect requires the Rac effector protein p21 activated kinase 1 (PAK1). Inhibition of Rac or PAK1 function by dominant negative constructs in endothelial cells in vivo inhibits growth factor-induced angiogenesis [90,91]. http://www.tkuhn.ch/bel2nanopub/RAAsYyvqim4nIjbm1cn0OelrzLq_aWE1uG8rdFGlx4gYc#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/14984767 http://www.tkuhn.ch/bel2nanopub/RAAsYyvqim4nIjbm1cn0OelrzLq_aWE1uG8rdFGlx4gYc#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAAsYyvqim4nIjbm1cn0OelrzLq_aWE1uG8rdFGlx4gYc#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/14984767 http://www.tkuhn.ch/bel2nanopub/RAAsYyvqim4nIjbm1cn0OelrzLq_aWE1uG8rdFGlx4gYc#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAAsYyvqim4nIjbm1cn0OelrzLq_aWE1uG8rdFGlx4gYc#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAAsYyvqim4nIjbm1cn0OelrzLq_aWE1uG8rdFGlx4gYc#_4 http://www.tkuhn.ch/bel2nanopub/RAAsYyvqim4nIjbm1cn0OelrzLq_aWE1uG8rdFGlx4gYc#pubinfo http://www.tkuhn.ch/bel2nanopub/RAAsYyvqim4nIjbm1cn0OelrzLq_aWE1uG8rdFGlx4gYc http://purl.org/dc/terms/created 2014-07-03T14:32:17.207+02:00 http://www.tkuhn.ch/bel2nanopub/RAAsYyvqim4nIjbm1cn0OelrzLq_aWE1uG8rdFGlx4gYc http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAAsYyvqim4nIjbm1cn0OelrzLq_aWE1uG8rdFGlx4gYc http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234