@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAAsYyvqim4nIjbm1cn0OelrzLq_aWE1uG8rdFGlx4gYc> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAAsYyvqim4nIjbm1cn0OelrzLq_aWE1uG8rdFGlx4gYc#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix sfam: <http://resource.belframework.org/belframework/20131211/namespace/selventa-protein-families/> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix obo: <http://purl.obolibrary.org/obo/> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 hasAgent: sub:_2;
    a go:0005525 .
  
  sub:_2 geneProductOf: sfam:RAC%20Family;
    a Protein: .
  
  sub:_3 occursIn: obo:CL_0000115, obo:UBERON_0004535, species:9606;
    rdf:object go:0001525;
    rdf:predicate belv:increases;
    rdf:subject sub:_1;
    a rdf:Statement .
  
  sub:assertion rdfs:label "gtp(p(SFAM:\"RAC Family\")) -> bp(GOBP:angiogenesis)" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_5;
    pav:version "20131211" .
  
  sub:_4 prov:value "Regulation of cell migration appears to implicate a cross talk with Rhofamily proteins. In migrating cells, PKB/Akt localizes to the leading edge [79], a site of high Rac activity [80]. In endothelial cells PKB/Akt has been reported to be both upstream and downstream of Rac and Cdc42 [81-83]. Endothelial cell migration induced by VEGFR2- stimulation involves integrin activation via a PI-3K and PKB/Akt-dependent signaling pathway [84]. Rho family GTPases. The small GTPases Rho, Rac and Cdc42 participate in the regulation of actin polymerization necessary for the formation of stress fibers, focal adhesions, lamellipodia and filopodia [85], and modulate cell proliferation and gene expression [86,87]. Integrin ligation activates Rho proteins by promoting GTP loading and translocation from the cytosol to the membrane [88]. Rac activity is essential for endothelial cell migration and angiogenesis [89,90] and this effect requires the Rac effector protein p21 activated kinase 1 (PAK1). Inhibition of Rac or PAK1 function by dominant negative constructs in endothelial cells in vivo inhibits growth factor-induced angiogenesis [90,91].";
    prov:wasQuotedFrom pubmed:14984767 .
  
  sub:_5 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:14984767;
    prov:wasDerivedFrom beldoc:, sub:_4 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:32:17.207+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}