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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAAoFpHAVj3FlgKUfP3_TSupFN03oH_CoNpnSRTard1N4#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAAoFpHAVj3FlgKUfP3_TSupFN03oH_CoNpnSRTard1N4#_5 http://www.w3.org/ns/prov#value We have found that activation of the MEK5-ERK5 pathway causes the phosphorylation and stabilization of c-Fos and Fra-1.Phosphorylation of c-Fos appears to be mediated by ERK5 and a kinase(s) lying downstream of ERK5, and the MEK5-ERK5 pathway-dependent phosphorylation sites on c-Fos are different from the ERK1/2 pathway-dependent ones. Interestingly, activation of the MEK5-ERK5 pathway, but not that of the ERK1/2 pathway, is found to markedly increase the transactivation activity of c-Fos. Furthermore, our results show that the C-terminal half of ERK5 is necessary for the maximal activation of the transactivation activity of c-Fos and Fra-1. http://www.tkuhn.ch/bel2nanopub/RAAoFpHAVj3FlgKUfP3_TSupFN03oH_CoNpnSRTard1N4#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12622723 http://www.tkuhn.ch/bel2nanopub/RAAoFpHAVj3FlgKUfP3_TSupFN03oH_CoNpnSRTard1N4#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAAoFpHAVj3FlgKUfP3_TSupFN03oH_CoNpnSRTard1N4#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12622723 http://www.tkuhn.ch/bel2nanopub/RAAoFpHAVj3FlgKUfP3_TSupFN03oH_CoNpnSRTard1N4#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAAoFpHAVj3FlgKUfP3_TSupFN03oH_CoNpnSRTard1N4#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAAoFpHAVj3FlgKUfP3_TSupFN03oH_CoNpnSRTard1N4#_5 http://www.tkuhn.ch/bel2nanopub/RAAoFpHAVj3FlgKUfP3_TSupFN03oH_CoNpnSRTard1N4#pubinfo http://www.tkuhn.ch/bel2nanopub/RAAoFpHAVj3FlgKUfP3_TSupFN03oH_CoNpnSRTard1N4 http://purl.org/dc/terms/created 2014-07-03T14:30:10.709+02:00 http://www.tkuhn.ch/bel2nanopub/RAAoFpHAVj3FlgKUfP3_TSupFN03oH_CoNpnSRTard1N4 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAAoFpHAVj3FlgKUfP3_TSupFN03oH_CoNpnSRTard1N4 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234