sub:provenance { beldoc:dce:description "Approximately 61,000 statements." ; dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ; dce:title "BEL Framework Large Corpus Document" ; pav:authoredBysub:_4 ; pav:version "20131211" . sub:_3prov:value "To study the functional consequences of RASSF1A expression in human cells, we made use of a tetracycline-inducible expression system (32) and the A549 lung cancer cell line, which is deficient in endogenous RASSF1A, p14Arf, and p16Ink4a expression (Supplementary Fig. S1A; ref. 35). In this model, addition of doxycycline induced transgenic expression of RASSF1A, which inhibited growth of lung cancer cells in vitro (Fig. 1A) and in vivo after s.c. transplantation into immunodeficient NOD/SCID mice (Fig. 1B)." ; prov:wasQuotedFrompubmed:19223555 . sub:_4rdfs:label "Selventa" . sub:assertionprov:hadPrimarySourcepubmed:19223555 ; prov:wasDerivedFrombeldoc: , sub:_3 . }