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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAAnxQ5dFRA4Cz-WQY7I-I1KRSPgGe5n5UhvoAsYF7sDo#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAAnxQ5dFRA4Cz-WQY7I-I1KRSPgGe5n5UhvoAsYF7sDo#_3 http://www.w3.org/ns/prov#value Cellular, local, and organismal responses to low O2 availability occur during processes such as anaerobic metabolism and wound healing and pathological conditions such as stroke and cancer. These responses include increases in glycolytic activity, vascularization, breathing, and red blood cell production. These responses are mediated in part by the hypoxia-inducible factors (HIFs), which receive information on O2 levels from a group of iron- and O2-dependent hydroxylases. Hypoxia mimics, such as cobalt chloride, nickel chloride, and deferoxamine, act to simulate hypoxia by altering the iron status of these hydroxylases. To determine whether these mimics are appropriate substitutes for the lower O2 tension evoked naturally, we compared transcriptional responses of a Hep3B cell line using high-density oligonucleotide arrays. A battery of core genes was identified that was shared by all four treatments (hypoxia, cobalt, nickel, and deferoxamine) including glycolytic enzymes, cell cycle regulators, and apoptotic genes. Importantly, cobalt, nickel, and deferoxamine influenced transcription of distinct sets of genes that were not affected by cellular hypoxia. These global responses to hypoxia indicate a balancing act between adaptation and programmed cell death and suggest caution in the use of hypoxia mimics as substitutes for the low O2 tension that occurs in vivo. http://www.tkuhn.ch/bel2nanopub/RAAnxQ5dFRA4Cz-WQY7I-I1KRSPgGe5n5UhvoAsYF7sDo#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15942021 http://www.tkuhn.ch/bel2nanopub/RAAnxQ5dFRA4Cz-WQY7I-I1KRSPgGe5n5UhvoAsYF7sDo#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAAnxQ5dFRA4Cz-WQY7I-I1KRSPgGe5n5UhvoAsYF7sDo#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15942021 http://www.tkuhn.ch/bel2nanopub/RAAnxQ5dFRA4Cz-WQY7I-I1KRSPgGe5n5UhvoAsYF7sDo#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAAnxQ5dFRA4Cz-WQY7I-I1KRSPgGe5n5UhvoAsYF7sDo#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAAnxQ5dFRA4Cz-WQY7I-I1KRSPgGe5n5UhvoAsYF7sDo#_3 http://www.tkuhn.ch/bel2nanopub/RAAnxQ5dFRA4Cz-WQY7I-I1KRSPgGe5n5UhvoAsYF7sDo#pubinfo http://www.tkuhn.ch/bel2nanopub/RAAnxQ5dFRA4Cz-WQY7I-I1KRSPgGe5n5UhvoAsYF7sDo http://purl.org/dc/terms/created 2014-07-03T14:32:46.051+02:00 http://www.tkuhn.ch/bel2nanopub/RAAnxQ5dFRA4Cz-WQY7I-I1KRSPgGe5n5UhvoAsYF7sDo http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAAnxQ5dFRA4Cz-WQY7I-I1KRSPgGe5n5UhvoAsYF7sDo http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234