http://www.tkuhn.ch/bel2nanopub/RAAmRVzP5f5WTtwP8YX2XKb_pxsNdibq-0LnoZ7dkfsyk#Head http://www.tkuhn.ch/bel2nanopub/RAAmRVzP5f5WTtwP8YX2XKb_pxsNdibq-0LnoZ7dkfsyk http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAAmRVzP5f5WTtwP8YX2XKb_pxsNdibq-0LnoZ7dkfsyk#assertion http://www.tkuhn.ch/bel2nanopub/RAAmRVzP5f5WTtwP8YX2XKb_pxsNdibq-0LnoZ7dkfsyk http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAAmRVzP5f5WTtwP8YX2XKb_pxsNdibq-0LnoZ7dkfsyk#provenance http://www.tkuhn.ch/bel2nanopub/RAAmRVzP5f5WTtwP8YX2XKb_pxsNdibq-0LnoZ7dkfsyk http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAAmRVzP5f5WTtwP8YX2XKb_pxsNdibq-0LnoZ7dkfsyk#pubinfo http://www.tkuhn.ch/bel2nanopub/RAAmRVzP5f5WTtwP8YX2XKb_pxsNdibq-0LnoZ7dkfsyk http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAAmRVzP5f5WTtwP8YX2XKb_pxsNdibq-0LnoZ7dkfsyk#assertion http://www.tkuhn.ch/bel2nanopub/RAAmRVzP5f5WTtwP8YX2XKb_pxsNdibq-0LnoZ7dkfsyk#_1 http://www.selventa.com/vocabulary/variantOf http://resource.belframework.org/belframework/1.0/namespace/selventa-named-human-protein-families/AKT%20Family http://www.tkuhn.ch/bel2nanopub/RAAmRVzP5f5WTtwP8YX2XKb_pxsNdibq-0LnoZ7dkfsyk#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00000 http://www.tkuhn.ch/bel2nanopub/RAAmRVzP5f5WTtwP8YX2XKb_pxsNdibq-0LnoZ7dkfsyk#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00696 http://www.tkuhn.ch/bel2nanopub/RAAmRVzP5f5WTtwP8YX2XKb_pxsNdibq-0LnoZ7dkfsyk#_2 http://semanticscience.org/resource/SIO_000139 http://www.tkuhn.ch/bel2nanopub/RAAmRVzP5f5WTtwP8YX2XKb_pxsNdibq-0LnoZ7dkfsyk#_3 http://www.tkuhn.ch/bel2nanopub/RAAmRVzP5f5WTtwP8YX2XKb_pxsNdibq-0LnoZ7dkfsyk#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0016301 http://www.tkuhn.ch/bel2nanopub/RAAmRVzP5f5WTtwP8YX2XKb_pxsNdibq-0LnoZ7dkfsyk#_3 http://purl.obolibrary.org/obo/RO_0002204 http://resource.belframework.org/belframework/1.0/namespace/selventa-named-human-protein-families/AKT%20Family http://www.tkuhn.ch/bel2nanopub/RAAmRVzP5f5WTtwP8YX2XKb_pxsNdibq-0LnoZ7dkfsyk#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAAmRVzP5f5WTtwP8YX2XKb_pxsNdibq-0LnoZ7dkfsyk#_4 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RAAmRVzP5f5WTtwP8YX2XKb_pxsNdibq-0LnoZ7dkfsyk#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAAmRVzP5f5WTtwP8YX2XKb_pxsNdibq-0LnoZ7dkfsyk#_2 http://www.tkuhn.ch/bel2nanopub/RAAmRVzP5f5WTtwP8YX2XKb_pxsNdibq-0LnoZ7dkfsyk#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/directlyIncreases http://www.tkuhn.ch/bel2nanopub/RAAmRVzP5f5WTtwP8YX2XKb_pxsNdibq-0LnoZ7dkfsyk#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RAAmRVzP5f5WTtwP8YX2XKb_pxsNdibq-0LnoZ7dkfsyk#_1 http://www.tkuhn.ch/bel2nanopub/RAAmRVzP5f5WTtwP8YX2XKb_pxsNdibq-0LnoZ7dkfsyk#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAAmRVzP5f5WTtwP8YX2XKb_pxsNdibq-0LnoZ7dkfsyk#assertion http://www.w3.org/2000/01/rdf-schema#label p(PFH:"AKT Family",pmod(P,S)) => kin(p(PFH:"AKT Family")) http://www.tkuhn.ch/bel2nanopub/RAAmRVzP5f5WTtwP8YX2XKb_pxsNdibq-0LnoZ7dkfsyk#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAAmRVzP5f5WTtwP8YX2XKb_pxsNdibq-0LnoZ7dkfsyk#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAAmRVzP5f5WTtwP8YX2XKb_pxsNdibq-0LnoZ7dkfsyk#_5 http://www.w3.org/ns/prov#value Activation of the protein p70s6k by mitogens leads to increased translation of a family of messenger RNAs that encode essential components of the protein synthetic apparatus. Activation of the kinase requires hierarchical phosphorylation at multiple sites, culminating in the phosphorylation of the threonine in position 229 (Thr229), in the catalytic domain. The homologous site in protein kinase B (PKB), Thr308, has been shown to be phosphorylated by the phosphoinositide-dependent protein kinase PDK1. A regulatory link between p70s6k and PKB was demonstrated, as PDK1 was found to selectively phosphorylate p70s6k at Thr229. More importantly, PDK1 activated p70s6k in vitro and in vivo, whereas the catalytically inactive PDK1 blocked insulin-induced activation of p70s6k. http://www.tkuhn.ch/bel2nanopub/RAAmRVzP5f5WTtwP8YX2XKb_pxsNdibq-0LnoZ7dkfsyk#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/9445476 http://www.tkuhn.ch/bel2nanopub/RAAmRVzP5f5WTtwP8YX2XKb_pxsNdibq-0LnoZ7dkfsyk#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAAmRVzP5f5WTtwP8YX2XKb_pxsNdibq-0LnoZ7dkfsyk#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/9445476 http://www.tkuhn.ch/bel2nanopub/RAAmRVzP5f5WTtwP8YX2XKb_pxsNdibq-0LnoZ7dkfsyk#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAAmRVzP5f5WTtwP8YX2XKb_pxsNdibq-0LnoZ7dkfsyk#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAAmRVzP5f5WTtwP8YX2XKb_pxsNdibq-0LnoZ7dkfsyk#_5 http://www.tkuhn.ch/bel2nanopub/RAAmRVzP5f5WTtwP8YX2XKb_pxsNdibq-0LnoZ7dkfsyk#pubinfo http://www.tkuhn.ch/bel2nanopub/RAAmRVzP5f5WTtwP8YX2XKb_pxsNdibq-0LnoZ7dkfsyk http://purl.org/dc/terms/created 2014-07-03T14:30:59.283+02:00 http://www.tkuhn.ch/bel2nanopub/RAAmRVzP5f5WTtwP8YX2XKb_pxsNdibq-0LnoZ7dkfsyk http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAAmRVzP5f5WTtwP8YX2XKb_pxsNdibq-0LnoZ7dkfsyk http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234