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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAAgnBkjPj55gsgDgsw-33FGCw3o6wcnIRaDQvFRijy4M#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAAgnBkjPj55gsgDgsw-33FGCw3o6wcnIRaDQvFRijy4M#_4 http://www.w3.org/ns/prov#value Activation of mTOR by insulin results in phosphorylation of downstream targets, e.g. 4E-BP1, S6K1 and ribosomal protein S6, resulting in activation of the mRNA-binding steps in translation initiation. Activation of the phosphatidylinositol 3-kinase-mammalian target of rapamycin signalling pathway by amino acids Although it is clear that amino acids, and in particular leucine, enhance phosphorylation of proteins downstream of mTOR, e.g. 4E-BP1 and S6K1, and indeed require mTOR to be active in order to be effective, whether or not they directly regulate mTOR activity is undecided. http://www.tkuhn.ch/bel2nanopub/RAAgnBkjPj55gsgDgsw-33FGCw3o6wcnIRaDQvFRijy4M#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15294054 http://www.tkuhn.ch/bel2nanopub/RAAgnBkjPj55gsgDgsw-33FGCw3o6wcnIRaDQvFRijy4M#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAAgnBkjPj55gsgDgsw-33FGCw3o6wcnIRaDQvFRijy4M#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15294054 http://www.tkuhn.ch/bel2nanopub/RAAgnBkjPj55gsgDgsw-33FGCw3o6wcnIRaDQvFRijy4M#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAAgnBkjPj55gsgDgsw-33FGCw3o6wcnIRaDQvFRijy4M#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAAgnBkjPj55gsgDgsw-33FGCw3o6wcnIRaDQvFRijy4M#_4 http://www.tkuhn.ch/bel2nanopub/RAAgnBkjPj55gsgDgsw-33FGCw3o6wcnIRaDQvFRijy4M#pubinfo http://www.tkuhn.ch/bel2nanopub/RAAgnBkjPj55gsgDgsw-33FGCw3o6wcnIRaDQvFRijy4M http://purl.org/dc/terms/created 2014-07-03T14:30:26.489+02:00 http://www.tkuhn.ch/bel2nanopub/RAAgnBkjPj55gsgDgsw-33FGCw3o6wcnIRaDQvFRijy4M http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAAgnBkjPj55gsgDgsw-33FGCw3o6wcnIRaDQvFRijy4M http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234