@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAAcrp5r0-Ijpx3lwqxFKWJ9I_Drnm3RJiBdMS3ErFEeE> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAAcrp5r0-Ijpx3lwqxFKWJ9I_Drnm3RJiBdMS3ErFEeE#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix RNA: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix obo: <http://purl.obolibrary.org/obo/> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 geneProductOf: hgnc:3665;
    a RNA: .
  
  sub:_2 occursIn: obo:CL_0000235, obo:UBERON_0004535, species:9606;
    rdf:object sub:_1;
    rdf:predicate belv:increases;
    rdf:subject go:0001666;
    a rdf:Statement .
  
  sub:assertion rdfs:label "bp(GOBP:\"response to hypoxia\") -> r(HGNC:FGF1)" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_4;
    pav:version "20131211" .
  
  sub:_3 prov:value " Effects of hypoxia on molecular determinants of angiogenesis Angiogenesis is a complex process, involving multiple gene products expressed by different cell types, all contributing to an integrated sequence of events44. Consistent with a major role for hypoxia in the overall process, a large number of genes involved in different steps of angiogenesis are independently responsive to hypoxia in tissue culture. Examples include nitric oxide synthases involved in governing vascular tone, growth factors such as VEGF, angiopoietins, fibroblast growth factors and their various receptors, and genes involved in matrix metabolism, including matrix metalloproteinases, plasminogen activator receptors and inhibitors, and collagen prolyl hydroxylase16, 17, 18, 19, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61 (Table 1). Similarly, many of the individual phenotypic processes in angiogenesis such as cell migration or endothelial tube formation can be induced by hypoxic tissue culture62, 63, 64. These analyses in isolated systems have sometimes apparently shown both positive and negative effects of hypoxia, for instance on endothelial proliferation65, 66, 67. It is not yet clear whether such phenomena reflect fundamentally different responses based on severity of hypoxia, or counter-regulatory controls that are normally integrated in a productive way.";
    prov:wasQuotedFrom pubmed:12778166 .
  
  sub:_4 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:12778166;
    prov:wasDerivedFrom beldoc:, sub:_3 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:32:02.702+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}