@prefix this: <http://rdf.disgenet.org/nanopublications.trig#NP425561.RAAaMq4LYZ6neIlCaFRNxb0pcdLZAZiM3rtgT9LaMe65k> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix sio: <http://semanticscience.org/resource/> .
@prefix ncit: <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#> .
@prefix lld: <http://linkedlifedata.com/resource/umls/id/> .
@prefix miriam-gene: <http://identifiers.org/ncbigene/> .
@prefix miriam-pubmed: <http://identifiers.org/pubmed/> .
@prefix eco: <http://purl.obolibrary.org/obo/eco.owl#> .
@prefix wi: <http://purl.org/ontology/wi/core#> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix pav: <http://purl.org/pav/2.0/> .
@prefix prv: <http://purl.org/net/provenance/ns#> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix dgn-np: <http://rdf.disgenet.org/nanopublications.trig#> .
@prefix dgn-gda: <http://rdf.disgenet.org/gene-disease-association.ttl#> .
@prefix dgn-void: <http://rdf.disgenet.org/v2.1.0/void.ttl#> .

dgn-np:NP425561.RAAaMq4LYZ6neIlCaFRNxb0pcdLZAZiM3rtgT9LaMe65k130_head {
  this: np:hasAssertion dgn-np:NP425561.RAAaMq4LYZ6neIlCaFRNxb0pcdLZAZiM3rtgT9LaMe65k130_assertion;
    np:hasProvenance dgn-np:NP425561.RAAaMq4LYZ6neIlCaFRNxb0pcdLZAZiM3rtgT9LaMe65k130_provenance;
    np:hasPublicationInfo dgn-np:NP425561.RAAaMq4LYZ6neIlCaFRNxb0pcdLZAZiM3rtgT9LaMe65k130_publicationInfo;
    a np:Nanopublication .
  
  dgn-np:NP425561.RAAaMq4LYZ6neIlCaFRNxb0pcdLZAZiM3rtgT9LaMe65k130_assertion a np:Assertion .
  
  dgn-np:NP425561.RAAaMq4LYZ6neIlCaFRNxb0pcdLZAZiM3rtgT9LaMe65k130_provenance a np:Provenance .
  
  dgn-np:NP425561.RAAaMq4LYZ6neIlCaFRNxb0pcdLZAZiM3rtgT9LaMe65k130_publicationInfo a
      np:PublicationInfo .
}

dgn-np:NP425561.RAAaMq4LYZ6neIlCaFRNxb0pcdLZAZiM3rtgT9LaMe65k130_assertion {
  miriam-gene:5062 a ncit:C16612 .
  
  lld:C1516170 a ncit:C7057 .
  
  dgn-gda:DGN8e306b851e7cb10a5c4040b358919540 sio:SIO_000628 miriam-gene:5062, lld:C1516170;
    a sio:SIO_001121 .
}

dgn-np:NP425561.RAAaMq4LYZ6neIlCaFRNxb0pcdLZAZiM3rtgT9LaMe65k130_provenance {
  dgn-np:NP425561.RAAaMq4LYZ6neIlCaFRNxb0pcdLZAZiM3rtgT9LaMe65k130_assertion dcterms:description
      "[Here we found that (1) LC treatment selectively inhibited cancer cell growth in vivo and in vitro; (2) LC treatment selectively induces the expression of p21(cip1) gene, mRNA and protein in cancer cells but not p27(kip1); (4) LC increases histone acetylation and induces accumulation of acetylated histones both in normal thymocytes and cancer cells; (5) LC directly inhibits HDAC I/II activities via binding to the active sites of HDAC and induces histone acetylation and lysine-acetylation accumulation in vitro; (6) LC treatment induces accumulation of acetylated histones in chromatin associated with the p21(cip1) gene but not p27(kip1) detected by ChIP assay.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en;
    wi:evidence dgn-void:source_evidence_literature;
    sio:SIO_000772 miriam-pubmed:23139833;
    prov:wasDerivedFrom dgn-void:befree-20140225;
    prov:wasGeneratedBy eco:ECO_0000203 .
  
  dgn-void:befree-20140225 pav:importedOn "2014-02-25"^^xsd:date .
  
  dgn-void:source_evidence_literature a eco:ECO_0000212;
    rdfs:comment "Gene-disease associations inferred from text-mining the literature."@en;
    rdfs:label "DisGeNET evidence - LITERATURE"@en .
}

dgn-np:NP425561.RAAaMq4LYZ6neIlCaFRNxb0pcdLZAZiM3rtgT9LaMe65k130_publicationInfo {
  this: dcterms:created "2014-10-02T12:36:12+02:00"^^xsd:dateTime;
    dcterms:rights <http://opendatacommons.org/licenses/odbl/1.0/>;
    dcterms:rightsHolder dgn-void:IBIGroup;
    dcterms:subject sio:SIO_000983;
    prv:usedData dgn-void:disgenetrdf;
    pav:authoredBy <http://orcid.org/0000-0001-5999-6269>, <http://orcid.org/0000-0002-7534-7661>,
      <http://orcid.org/0000-0002-9383-528X>, <http://orcid.org/0000-0003-0169-8159>, <http://orcid.org/0000-0003-1244-7654>;
    pav:createdBy <http://orcid.org/0000-0003-0169-8159>;
    pav:version "v2.1.0.0" .
  
  dgn-void:disgenetrdf pav:version "v2.1.0" .
}