http://www.tkuhn.ch/bel2nanopub/RAAQ6DR5alYF1mpZ76mcKCJUbskRYf1hkxiK9C2NJSaB8#Head http://www.tkuhn.ch/bel2nanopub/RAAQ6DR5alYF1mpZ76mcKCJUbskRYf1hkxiK9C2NJSaB8 http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAAQ6DR5alYF1mpZ76mcKCJUbskRYf1hkxiK9C2NJSaB8#assertion http://www.tkuhn.ch/bel2nanopub/RAAQ6DR5alYF1mpZ76mcKCJUbskRYf1hkxiK9C2NJSaB8 http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAAQ6DR5alYF1mpZ76mcKCJUbskRYf1hkxiK9C2NJSaB8#provenance http://www.tkuhn.ch/bel2nanopub/RAAQ6DR5alYF1mpZ76mcKCJUbskRYf1hkxiK9C2NJSaB8 http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAAQ6DR5alYF1mpZ76mcKCJUbskRYf1hkxiK9C2NJSaB8#pubinfo http://www.tkuhn.ch/bel2nanopub/RAAQ6DR5alYF1mpZ76mcKCJUbskRYf1hkxiK9C2NJSaB8 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAAQ6DR5alYF1mpZ76mcKCJUbskRYf1hkxiK9C2NJSaB8#assertion http://www.tkuhn.ch/bel2nanopub/RAAQ6DR5alYF1mpZ76mcKCJUbskRYf1hkxiK9C2NJSaB8#_1 http://purl.obolibrary.org/obo/RO_0002204 http://www.informatics.jax.org/marker/MGI:1099809 http://www.tkuhn.ch/bel2nanopub/RAAQ6DR5alYF1mpZ76mcKCJUbskRYf1hkxiK9C2NJSaB8#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAAQ6DR5alYF1mpZ76mcKCJUbskRYf1hkxiK9C2NJSaB8#_2 http://semanticscience.org/resource/SIO_000139 http://www.tkuhn.ch/bel2nanopub/RAAQ6DR5alYF1mpZ76mcKCJUbskRYf1hkxiK9C2NJSaB8#_3 http://www.tkuhn.ch/bel2nanopub/RAAQ6DR5alYF1mpZ76mcKCJUbskRYf1hkxiK9C2NJSaB8#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0016301 http://www.tkuhn.ch/bel2nanopub/RAAQ6DR5alYF1mpZ76mcKCJUbskRYf1hkxiK9C2NJSaB8#_3 http://purl.obolibrary.org/obo/RO_0002204 http://www.informatics.jax.org/marker/MGI:95523 http://www.tkuhn.ch/bel2nanopub/RAAQ6DR5alYF1mpZ76mcKCJUbskRYf1hkxiK9C2NJSaB8#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAAQ6DR5alYF1mpZ76mcKCJUbskRYf1hkxiK9C2NJSaB8#_4 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.obolibrary.org/obo/CL_0000066 http://www.tkuhn.ch/bel2nanopub/RAAQ6DR5alYF1mpZ76mcKCJUbskRYf1hkxiK9C2NJSaB8#_4 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.obolibrary.org/obo/UBERON_0002048 http://www.tkuhn.ch/bel2nanopub/RAAQ6DR5alYF1mpZ76mcKCJUbskRYf1hkxiK9C2NJSaB8#_4 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090 http://www.tkuhn.ch/bel2nanopub/RAAQ6DR5alYF1mpZ76mcKCJUbskRYf1hkxiK9C2NJSaB8#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAAQ6DR5alYF1mpZ76mcKCJUbskRYf1hkxiK9C2NJSaB8#_2 http://www.tkuhn.ch/bel2nanopub/RAAQ6DR5alYF1mpZ76mcKCJUbskRYf1hkxiK9C2NJSaB8#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/directlyIncreases http://www.tkuhn.ch/bel2nanopub/RAAQ6DR5alYF1mpZ76mcKCJUbskRYf1hkxiK9C2NJSaB8#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RAAQ6DR5alYF1mpZ76mcKCJUbskRYf1hkxiK9C2NJSaB8#_1 http://www.tkuhn.ch/bel2nanopub/RAAQ6DR5alYF1mpZ76mcKCJUbskRYf1hkxiK9C2NJSaB8#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAAQ6DR5alYF1mpZ76mcKCJUbskRYf1hkxiK9C2NJSaB8#assertion http://www.w3.org/2000/01/rdf-schema#label p(MGI:Fgf10) => kin(p(MGI:Fgfr2)) http://www.tkuhn.ch/bel2nanopub/RAAQ6DR5alYF1mpZ76mcKCJUbskRYf1hkxiK9C2NJSaB8#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAAQ6DR5alYF1mpZ76mcKCJUbskRYf1hkxiK9C2NJSaB8#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAAQ6DR5alYF1mpZ76mcKCJUbskRYf1hkxiK9C2NJSaB8#_5 http://www.w3.org/ns/prov#value We found that expression of Elf5 was induced by FGF7 and FGF10, ligands that primarily bind FGFR2b. To further define the pathways by which FGFs activate Elf5 expression, we cultured E11.5 lung tips in the presence of compounds to inhibit FGF receptors (SU5402), PI3-Kinase/Akt-mediated signaling (LY294002), and MAP Kinase/Erk-mediated signaling (U0126). We found that SU5402 and LY294002 significantly reduced Elf5 expression, whereas U0126 had no effect. LY294002 also reduced Elf5 expression in cultures of purified epithelium. Finally, pAkt was coexpressed with Elf5 in the proximal epithelial airways of E17.5 lungs. These results demonstrate that Elf5 is an FGF-sensitive transcription factor in the lung with a dynamic pattern of expression and that FGF regulation of Elf5 by means of FGFR2b occurs through the PI3-Kinase/Akt pathway. http://www.tkuhn.ch/bel2nanopub/RAAQ6DR5alYF1mpZ76mcKCJUbskRYf1hkxiK9C2NJSaB8#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/17394208 http://www.tkuhn.ch/bel2nanopub/RAAQ6DR5alYF1mpZ76mcKCJUbskRYf1hkxiK9C2NJSaB8#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAAQ6DR5alYF1mpZ76mcKCJUbskRYf1hkxiK9C2NJSaB8#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/17394208 http://www.tkuhn.ch/bel2nanopub/RAAQ6DR5alYF1mpZ76mcKCJUbskRYf1hkxiK9C2NJSaB8#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAAQ6DR5alYF1mpZ76mcKCJUbskRYf1hkxiK9C2NJSaB8#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAAQ6DR5alYF1mpZ76mcKCJUbskRYf1hkxiK9C2NJSaB8#_5 http://www.tkuhn.ch/bel2nanopub/RAAQ6DR5alYF1mpZ76mcKCJUbskRYf1hkxiK9C2NJSaB8#pubinfo http://www.tkuhn.ch/bel2nanopub/RAAQ6DR5alYF1mpZ76mcKCJUbskRYf1hkxiK9C2NJSaB8 http://purl.org/dc/terms/created 2014-07-03T14:33:09.750+02:00 http://www.tkuhn.ch/bel2nanopub/RAAQ6DR5alYF1mpZ76mcKCJUbskRYf1hkxiK9C2NJSaB8 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAAQ6DR5alYF1mpZ76mcKCJUbskRYf1hkxiK9C2NJSaB8 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234